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Table 6 Effects of MK-0626 plus GLP-1 on plasma K + and hematocrit

From: Acute hemodynamic and renal effects of glucagon-like peptide 1 analog and dipeptidyl peptidase-4 inhibitor in rats

Group

K + (mmol/l)

Hematocrit (%)

Baseline→treatment

Baseline→treatment

MK-0626 + Saline

4.4 ± 0.14→4.2 ± 0.10

40.0 ± 0.8→38.2 ± 0.6

MK-0626 + GLP-1 2.4 pmol/kg/min

4.5 ± 0.08→3.8 ± 0.09**

40.1 ± 0.7→39.7 ± 0.5

MK-0626 + GLP-1 4.8 pmol/kg/min

4.4 ± 0.09→3.6 ± 0.05**

39.6 ± 0.6→39.8 ± 0.5

MK-0626 + GLP-1 9.6 pmol/kg/min

4.4 ± 0.10→3.6 ± 0.08**

40.5 ± 0.5→41.1 ± 0.6

  1. **p < 0.01 vs. baseline. Baseline refers to the 20 minutes period prior to IV administration of saline or MK-0626.
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Cardiovascular Diabetology

ISSN: 1475-2840