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Table 4 Effects of MK-0626 plus GLP-1 on blood pressure and heart rate

From: Acute hemodynamic and renal effects of glucagon-like peptide 1 analog and dipeptidyl peptidase-4 inhibitor in rats

 

BP (mmHg)

HR (bpm)

Baseline→treatment

Baseline→treatment

MK-0626 + saline

123.5 ± 3.7 →121.9 ± 3.9

381.2 ± 10.0 → 380.9 ± 10.3

MK-0626 + GLP-1 2.4 pmol/kg/min

121.1 ± 4.8 →118.7 ± 3.7

365.1 ± 12.6 →385.1 ± 8.6

MK-0626 + GLP-1 4.8 pmol/kg/min

125.7 ± 3.7 →123.5 ± 1.6

401.0 ± 6.5 →406.7 ± 9.2

MK-0626 + GLP-1 9.6 pmol/kg/min

124.7 ± 3.0→122.0 ± 2.3

386.9 ± 8.7→406.1 ± 8.5*

  1. *P < 0.05 vs. baseline. Baseline refers to the 20 minutes period prior to IV administration of saline or MK-0626.
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Cardiovascular Diabetology

ISSN: 1475-2840