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Table 4 Effects of MK-0626 plus GLP-1 on blood pressure and heart rate

From: Acute hemodynamic and renal effects of glucagon-like peptide 1 analog and dipeptidyl peptidase-4 inhibitor in rats

  BP (mmHg) HR (bpm)
Baseline→treatment Baseline→treatment
MK-0626 + saline 123.5 ± 3.7 →121.9 ± 3.9 381.2 ± 10.0 → 380.9 ± 10.3
MK-0626 + GLP-1 2.4 pmol/kg/min 121.1 ± 4.8 →118.7 ± 3.7 365.1 ± 12.6 →385.1 ± 8.6
MK-0626 + GLP-1 4.8 pmol/kg/min 125.7 ± 3.7 →123.5 ± 1.6 401.0 ± 6.5 →406.7 ± 9.2
MK-0626 + GLP-1 9.6 pmol/kg/min 124.7 ± 3.0→122.0 ± 2.3 386.9 ± 8.7→406.1 ± 8.5*
  1. *P < 0.05 vs. baseline. Baseline refers to the 20 minutes period prior to IV administration of saline or MK-0626.