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Table 5 Exclusion criteria

From: Design and rationale for the randomised, double-blinded, placebo-controlled Liraglutide to Improve corONary haemodynamics during Exercise streSS (LIONESS) crossover study

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An abnormal resting electrocardiogram including atrial fibrillation, bundle brunch aberration or other conduction disturbance

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Pre-existing significant left ventricular systolic dysfunction (ejection fraction <40%)

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Pre-existing ischaemic or non-ischaemic cardiomyopathy

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Pre-existing haemodynamically significant valvular heart disease

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Inability to safely negotiate an exercise treadmill

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Patients with Type 1 diabetes mellitus

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Patients with Type 2 diabetes mellitus taking oral and/or subcutaneous anti-diabetic therapy

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Patients with a personal or family history of medullary thyroid carcinoma

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Patients with Multiple Endocrine Neoplasia syndrome type 2

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Patients with acute renal failure or deteriorating renal function