• | Change in total exercise time during sequential exercise tolerance testing performed over a 6-week study period |
• | Change in time to 0.1 mV ST-segment depression during sequential exercise tolerance testing performed over a 6-week study period |
• | Change in time to maximum ST-segment depression during sequential exercise tolerance testing performed over a 6-week study period |
• | Change in recovery time to 0.05 mV ST-segment depression during sequential exercise tolerance testing performed over a 6-week study period |
• | Evidence of hypoglycaemia through twice-daily home blood glucose monitoring and once-weekly random serum glucose measurements |
• | Evidence of renal dysfunction through once-weekly monitoring of serum creatinine, electrolytes and estimated glomerular filtration rate |
• | Evidence of acute pancreatitis through once weekly monitoring of serum amylase alongside telephone and once-weekly face-to-face study visits |