Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics

Pretorius, Etheresia; Bester, Janette; Vermeulen, Natasha; Alummoottil, Sajee; Soma, Prashilla; Buys, Antoinette V; Kell, Douglas B

doi:10.1186/s12933-015-0192-5

Cardiovascular Diabetology

Table 4 Demographics, iron, HbA1c levels and medication usage of Type II diabetes patients

From: Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics

Sample number	Gender	Age	Iron (μmol.L ⁻¹ ) 11.6-31.3	Transferrin (g.L ⁻¹ ) 2.2-3.7	% saturation 20 -50%	Serum ferritin (ng.mL ^-1) M = 20-250 F = 10-120	HbA1c (%) <7%	Dyslipidemia: Simvastatin Atorvastatin	Met-formin/Oral	Actrapid Humulin Protoph-ane Actra-phane	HT: Coversyl Amlodopine Carvedilol Adalat	Aspirin/Disprin
1	M	68	25.5	3.6	28	67		x	x		x	x
2	M	56	49	3	65	86	11.9		x		x
3	M	71	28.1	2.2	51	210	8.3		x		x
4	M	80	15.5	2.6	24	96	7	x	x		x	x
5	M	37	18.5	2.8	26	191	7.6		x
6	M	56	*10.6*	2.7	16	39	7.7		x		x
7	F	71	19.9	2.3	35	20	8	x	x		x	x
8	F	48	15.1	3.3	18	46	6.2	x	x		x	x
9	F	70	*5.2*	3.9	5	7	7.5		x		x
10	F	82	33.6	3	45	101	8.9	x	x		x	x
11	M	62	25.6	2.3	45	202	5.9		x		x
12	M	71	17.8	2.4	30	243	10.5	x	x		x	x
13	M	70	19.7	2.2	36	75	10.4		x		x
14	F	58	36.5	2.9	50	164	6.0		x
15	F	61	18.6	2.8	27	29	8.2		x		x
16	M	56	32.1	2.9	44	152	8.6	x	x		x	x
17	M	42	40.7	2.3	71	217	13.6		x
18	F	62	16.2	4.1	16	24	10.6	x	x		x	x
19	M	72	19.8	*2.1*	38	332	6.7		x	x	x	x
20	M	59	18.5	2.8	26	191	?	x	x
21	M	75	14	*1.7*	33	218	6.6		x	x	x	x
22	M	41	28.2	3	38	235	8.3	x	x	x		x
23	F	81	23.8	2.3	41	62	9	x		x	x	x
24	M	41	33.4	2.7	49	101	5.5	x	x	x		x
25	M	80	39.5	2.7	59	142	6.8	x	x		x
26	M	64	13.2	2.3	23	50	?		x	x
27	M	63	22.9	2.4	38	265	10.2	x	x	x	x	x
28	F	49	7.1	3.4	8	12	6.8	x	x	x	x
29	M	72	25.3	2.4	42	386	6.7		x	x	x	x
30	M	46	21	2.4	35	233	11.6		x
31	M	40	14.5	2.4	24	96	8.7			x	x
32	M	55	10.3	2.2	19	88	5.8		x	x	x
33	F	62	BLOOD CLOTTED				8.2	x			x
34	M	52	25.9	3	35	155			x		x
35	F	59	18.5	2.5	30	125	11.6	x		x	x
36	F	58	16.5	2.5	26	79	6.0	x	x	x	x	x
37	F	62	14.1	2.9	19	64	10.2	x	x	x	x
38	M	60	*6.1*	2.6	9	93	7.5	x	x	x	x	x
39	F	57	24	2.7	36	60	8.0	x	x	x	x	x
40	F	63	31.4	2.5	50	77	7.6	x	x	x	x
41	M	59	15.4	2.8	22	151	8.5	x		x	x	x
42	M	73	29.5	2.9	51	154	8.0	x		x	x
43	F	58	20.3	2	41	81	10.6	x	x	x	x
44	F	66	28.6	2.6	44	359	10.0	x	x	x	x
45	M	60	18	2.4	30	192	12.2	x	x	x	x
46	F	69	*9.6*	2.3	17	74	7.4	x	x	x	x
47	M	62	21.1	3.1	27	28	9.2	x	x		x
48	M	58	28.2	2.8	40	605	11.9	x	x	x	x	x
49	F	62	12.4	2.2	23	58	11.3	x	x		x	x
50	M	61	23	*1.9*	48	1097	6.9	x		x	x	x
51	M	73	54.9	2.4	92	100		x	x		x	x
52	F	45	8	3.7	9	9	11.6	x		x	x	x
53	F	62	42.3	2.4	71	198	8		x		x
54	F	53	BLOOD CLOTTED				10.9	x		x	x	x
55	F	55	13.1	2.2	24	189	6.3	x	x	x	x	x
56	M	56	27	2.6	42	64	12.1	x	x	x	x
57	F	70	17.8	3	24	23	11.6	x		x	x	x
58	F	59	34.1	2.7	51	56	5.8	x	x		x	x
59	M	66	32.3	2.7	48	123	11.9	x	x	x	x	x
60	F	54	BLOOD CLOTTED				15.1	x		x	x
61	M	65	19.3	2.8	28	57	7.0	x		x	x
62	F	56	16.6	2.6	26	24	11.1	x	x	x	x
63	F	59	20.4	3.6	23	149
64	F	64	*7.3*	2.3	13	82	9.0			x	x	x
65	M	32	16.8	3.2	21	58
66	M	52	129.6 checked	3.2	>95	55	8.1	x	x	x	x	x
67	M	52	14.5	2.3	25	151	12.2	x		x	x
68	F	49	14.2	2.7	21	17	13.5		x		x
69	F	42	6	3.4	7	9	8.3	x	x	x	x

Normal (healthy values) is given in the heading. Bold values are above and italic values below the reference (normal) range.

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