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Table 1 Clinical and biochemical characteristics of participants

From: Serum fibroblast growth factor 21 levels is associated with lower extremity atherosclerotic disease in Chinese female diabetic patients

Variables

Men

P

Women

P

LEAD

Non-LEAD

LEAD

Non-LEAD

Age(year)

61.75 ± 10.31

47.55 ± 10.07

<0.001

64.40 ± 9.79

56.62 ± 9.52

<0.001

Diabetes duration(year)

10(5–15)

3(0.48-10)

<0.001

13.14 ± 7.73

7.85 ± 5.64

<0.001

Body mass index(kg/cm2)

23.59 ± 3.53

25.99 ± 3.20

0.194

25.12 ± 3.83

25.37 ± 3.89

0.655

Waist circumference(cm)

93.23 ± 10.89

94.80 ± 10.17

0.273

91.19 ± 11.35

88.02 ± 10.49

0.055

Systolic blood pressure(mmHg)

130(120–140)

130(120–140)

0.503

135(123.5-150)

129(120–135)

<0.001

Diastolic blood pressure(mmHg)

80(70–85)

80(78–90)

0.010

80(75–85)

80(70–85)

0.268

Fasting plasma glucose(mmol/L)

6.88(5.92-9.07)

7.92(6.50-10.36)

0.007

8.03 ± 2.62

2.97 ± 0.91

0.409

2 h postprandial plasma glucose(mmol/L)

12.96 ± 4.40

13.73 ± 4.53

0.212

14.31 ± 4.57

13.48 ± 4.61

0.232

Fasting C-peptide(ng/ml)

1.93 ± 1.03

2.12 ± 1.13

0.213

1.95 ± 1.07

2.07 ± 1.15

0.472

2-h postprandial C peptide(ng/ml)

4.98 ± 3.18

5.07 ± 3.50

0.854

4.90 ± 3.26

5.11 ± 2.99

0.664

Total cholesterol(mmol/L)

4.46 ± 1.11

4.98 ± 1.17

0.001

4.92 ± 1.10

5.08 ± 1.16

0.352

Triglyceride(mmol/L)

1.92(1.16-3.63)

1.40(0.93-2.10)

0.005

1.42(1.05-1.93)

1.46(0.98-2)

0.720

High-density lipoprotein cholesterol(mmol/L)

1.00 ± 0.24

0.97 ± 0.21

0.397

1.15 ± 0.32

1.18 ± 0.33

0.481

Low-density lipoprotein cholesterol(mmol/L)

2.63 ± 0.89

2.96 ± 0.80

0.006

2.86 ± 0.97

2.97 ± 0.91

0.409

Glycated hemoglobin A1c(%)

8.0(7.1-9.85)

9.1(7.45-10.85)

0.023

8.82 ± 1.86

8.62 ± 1.85

0.459

Glycated serum albumin(%)

22.30 ± 7.18

24.44 ± 8.07

0.044

20.9(17.75-26.30)

20.10(17.20-25.3)

0.364

Alanine aminotransferase(U/L)

21(14–27)

24(18–36.5)

0.065

18(13–31.75)

22(14.75-30)

0.303

Aspartate aminotransferase(U/L)

19(16–23)

19(15–28)

0.423

19(16–24)

20(15–25.5)

0.894

γ-glutamyl transpeptidase(U/L)

27(19–39)

31(21–42.5)

0.065

23(16.75-39)

28(18.50-44)

0.160

Glomerular filtration rate(ml/min/1.73 m2)

97.04 ± 24.04

96.34 ± 24.92

0.845

94.67 ± 25.79

98.37 ± 23.23

0.355

C reactive protein(mg/L)

1.67(0.64-2.57)

1.10(0.56-2.35)

0.347

1.3(0.53-2.65)

1.45(0.75-3.11)

0.256

Femoral intima-media thickness(mm)

0.85 ± 0.06

0.67 ± 0.12

<0.001

0.86 ± 0.03

0.70 ± 0.11

<0.001

Smoking(%)

55.8

54.9

0.888

0.8

2.7

0.278

Drinking(%)

24.5

19.5

0.233

1.6

1.4

0.903

Hypertension(%)

60.7

36.6

<0.001

62.7

37.0

<0.001

Anti-hypertensive therapy(%)

47.1

18.9

<0.001

48.6

20.3

<0.001

Anti-diabetic therapy(%)

78.9

77.1

0.732

68.9

66.4

0.453

Lipid-lowing therapy(%)

15.8

14.3

0.677

12.8

10.3

0.566

Estradiol

115.24 ± 58.72

116.54 ± 56.01

0.889

70.94(38.73-104.91)

88.95(50.10-165.27)

0.039

Testosterone

12.61 ± 5.25

12.64 ± 4.56

0.972

1.18(0.89-1.55)

1.26(0.94-1.69)

0.610

Progestogen

1.04(0.75-1.47)

1.03(0.71-1.33)

0.516

0.82(0.65-1.42)

0.80(0.64-1.90)

0.756

Follicle-Stimulating Hormone

9.43(6.40-14.41)

6.50(4.00-9.04)

<0.001

52.53 ± 23.61

38.08 ± 25.33

0.001

Luteinizing hormone

5.92(3.98-9.56)

4.96(3.24-6.48)

0.002

23.78 ± 10.53

20.16 ± 13.69

0.960

Prolactin

168.83(136.86-214.16)

171.39(109.74-242.44)

0.002

193.70 ± 85.48

185.66 ± 138.83

0.707

Dehydroepiandrosterone sulfate

201.13 ± 106.74

260.10 ± 117.77

0.001

126.50 ± 66.74

173.73 ± 81.99

<0.001