Figure 2

Effects of candesartan on nociceptive, skin microcirculation and neurovascular function. (a) Randall-Sellito tail pressure test. Mechanical withdrawal thresholds to nociceptive tail pressure. (b) Endothelium-dependent vasodilation. Maximal percentage of vasodilation from baseline in response to iontophoretic delivery of Ach. (c) Cutaneous typical laser Doppler blood flow response during a progressive increase of pressure in a control mice (black) and in a diabetic mice (red). P: start of pressure, a.u.: arbitrary units. (d) Pressure-induced vasodilation. Maximal percentage of vasodilation from baseline during localpressure application. (n = 10 in each group,non-parametric Kruskal-Wallis test followed by Dunn’s post-hoc test, *P < 0.05, **P < 0.01, ***P < 0.001)Ach: Acetylcholine, LDF:Laser Doppler Flowmetry.