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Figure 3 | Cardiovascular Diabetology

Figure 3

From: Liraglutide attenuates high glucose-induced abnormal cell migration, proliferation, and apoptosis of vascular smooth muscle cells by activating the GLP-1 receptor, and inhibiting ERK1/2 and PI3K/Akt signaling pathways

Figure 3

Liraglutide (LIRA) inhibited high glucose (HG)-induced migration in cultured vascular smooth muscle cells (VSMCs). (A) Transwell filters were stained with hematoxylin to visualize migrated cells (200× magnification). (B) Quantitation of migrated VSMCs in the Transwell migration assay; * p < 0.01 vs. control; # p < 0.01 vs. HG. (C) Confluent VSMCs were wounded and each scratch was imaged at 0 and 24 h after wounding. The wound gaps in each culture were measured to indicate the migration capacity of VSMCs. (D) Quantification of the wound area in the scratch assays; * p < 0.01 vs. control; # p < 0.05 vs. HG. The results are presented as mean ± standard deviation from three independent experiments. MG = mannitol, osmotic control.

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Cardiovascular Diabetology

ISSN: 1475-2840