Skip to main content

Table 3 Mean changes in parameters from baseline to end point

From: Association among weight change, glycemic control, and markers of cardiovascular risk with exenatide once weekly: a pooled analysis of patients with type 2 diabetes

Parameter, mean (SE) [95% CI] Quartile 1 Quartile 2 Quartile 3 Quartile 4 All Patients
(n = 455) (n = 458) (n = 450) (n = 455) (N = 1830)
Weight (kg) −7.0 (0.15) −3.0 (0.03) −1.0 (0.03) 1.5 (0.09) −2.4 (0.09)
[−7.3, −6.7] [−3.0, −2.9] [−1.1, −1.0] [1.4, 1.7] [−2.5, −2.2]
A1C (%) −1.7 (0.05) −1.4 (0.05) −1.2 (0.06) −1.3 (0.05) −1.4 (0.03)
[−1.8, −1.6] [−1.5, −1.3] [−1.3, −1.1] [−1.4, −1.2] [−1.5, −1.3]
FPG (mg/dL) −43.5 (2.30) −38.3 (2.29) −31.7 (2.13) −29.1 (2.50) −35.7 (1.16)
[−48.0, −39.0] [−42.8, −33.8] [−35.9, −27.6] [−34.1, −24.2] [−38.0, −33.5]
SBP (mm Hg) −5.8 (0.71) −3.7 (0.68) −3.1 (0.60) −0.5 (0.60) −3.3 (0.33)
[−7.2, −4.4] [−5.1, −2.4] [−4.2, −1.9] [−1.7, 0.7] [−3.9, −2.6]
DBP (mm Hg) −1.1 (0.43) −1.4 (0.41) −1.1 (0.40) 0.3 (0.44) −0.8 (0.21)
[−1.9, −0.2] [−2.2, −0.6] [−1.9, −0.3] [−0.5, 1.2] [−1.2, −0.4]
HR (beats per minute) 3.4 (0.48) 2.8 (0.44) 2.2 (0.46) 2.9 (0.48) 2.8 (0.23)
[2.5, 4.4] [1.9, 3.7] [1.3, 3.1] [1.9, 3.8] [2.4, 3.3]
HDL-C (mg/dL) 0.9 (0.31) 0.7 (0.30) 0.0 (0.33) −0.2 (0.34) 0.4 (0.16)
[0.3, 1.5] [0.2, 1.3] [−0.6, 0.7] [−0.9, 0.5] [0.1, 0.7]
LDL-C (mg/dL) −6.1 (1.23) −5.9 (1.15) −1.3 (1.25) −1.0 (1.36) −3.6 (0.63)
[−8.5, −3.6] [−8.2, −3.7] [−3.8, 1.1] [−3.7, 1.7] [−4.8, −2.4]
Total cholesterol (mg/dL) −9.3 (1.53) −8.2 (1.39) −2.5 (1.47) −1.5 (1.62) −5.4 (0.76)
[−12.3, −6.3] [−11.0, −5.5] [−5.4, 0.4] [−4.7, 1.7] [−6.9, −3.9]
Triglycerides (mg/dL) −26.1 (7.40) −19.7 (5.70) −6.2 (4.64) 0.5 (5.99) −13.0 (3.02)
[−40.7, −11.6] [−30.9, −8.5] [−15.3, 2.9] [−11.3, 12.3] [−19.0, −7.1]
ALT (U/L) −8.2 (0.67) −3.3 (0.78) −2.9 (0.76) 1.2 (1.44) −3.3 (0.48)
[−9.6, −6.9] [−4.8, −1.8] [−4.4, −1.4] [−1.7, 4.0] [−4.3, −2.4]
AST (U/L) −5.9 (0.77) −3.3 (0.82) −1.2 (0.83) −1.5 (1.06) −3.2 (0.44)
[−7.5, −4.4] [−4.9, −1.7] [−2.8, 0.5] [−3.6, 0.6] [−4.1, −2.3]
  1. A1C: glycated hemoglobin; ALT: alanine aminotransferase; AST: aspartate aminotransferase; CI: confidence interval; DBP: diastolic blood pressure; FPG: fasting plasma glucose; HDL-C: high-density lipoprotein cholesterol; HR: heart rate; LDL-C: low-density lipoprotein cholesterol; SBP: systolic blood pressure.