Association among weight change, glycemic control, and markers of cardiovascular risk with exenatide once weekly: a pooled analysis of patients with type 2 diabetes

Lawrence Blonde; Richard Pencek; Leigh MacConell

doi:10.1186/s12933-014-0171-2

Cardiovascular Diabetology

Table 2 Patient demographics and clinical characteristics

From: Association among weight change, glycemic control, and markers of cardiovascular risk with exenatide once weekly: a pooled analysis of patients with type 2 diabetes

Characteristic	Quartile 1 (−37.7 to −4.1 kg) ^a (n = 455)	Quartile 2 (−4.1 to −2.0 kg) ^a (n = 458)	Quartile 3 (−2.0 to −0.1 kg) ^a (n = 450)	Quartile 4 (−0.1 to +21.3 kg) ^a (n = 455)	Total (N = 1830)
Male, n (%)	223 (49.0)	249 (54.4)	257 (57.1)	283 (62.2)	1015 (55.5)
Age (y), mean (SD)	56 (9)	57 (10)	55 (10)	54 (11)	55 (10)
Known diabetes duration (y), mean (SD)	7 (6)	7 (6)	7 (6)	6 (5)	7 (6)
Race, n (%)
White	320 (70.3)	284 (62.0)	245 (54.4)	251 (55.2)	1104 (60.3)
Black	8 (1.8)	9 (2.0)	14 (3.1)	16 (3.5)	48 (2.6)
Hispanic	32 (7.0)	36 (7.9)	34 (7.6)	42 (9.2)	147 (8.0)
Asian	89 (19.6)	123 (26.9)	153 (34.0)	142 (31.2)	511 (27.9)
Other	6 (1.3)	6 (2.6)	4 (0.9)	4 (0.9)	20 (1.1)
Glucose-lowering background treatment, n (%)^b
Diet and exercise only	72 (15.8)	52 (11.4)	72 (16.0)	90 (19.8)	291 (15.9)
Insulin	3 (0.7)	1 (0.2)	3 (0.7)	1 (0.2)	8 (0.4)
Metformin	373 (82.0)	388 (84.7)	355 (78.9)	330 (72.5)	1453 (79.4)
Thiazolidinedione	22 (4.8)	19 (4.1)	27 (6.0)	32 (7.0)	100 (5.5)
Sulfonylurea	172 (37.8)	212 (46.3)	207 (46.0)	201 (44.2)	798 (43.6)
A1C (%), mean (SD)	8.3 (1.0)	8.4 (1.0)	8.5 (1.1)	8.7 (1.1)	8.5 (1.1)
FPG (mg/dL), mean (SD)	167.0 (44.2)	170.9 (45.7)	170.9 (46.2)	175.6 (50.8)	171.2 (46.9)
Body weight (kg), mean (SD)	93.7 (21.0)	85.3 (18.9)	85.3 (19.1)	87.7 (21.3)	88.0 (20.4)
BMI (kg/m²)
Mean (SD)	33.3 (5.7)	30.8 (5.6)	30.8 (5.3)	30.9 (5.6)	31.5 (5.6)
Category
<30	143 (31.4)	222 (48.5)	216 (48.0)	217 (47.7)	801 (43.8)
≥30	310 (68.1)	235 (51.3)	228 (50.7)	236 (51.9)	1018 (55.6)
Missing	2 (0.4)	1 (0.2)	6 (1.3)	2 (0.4)	11 (0.6)
SBP (mm Hg), mean (SD)	130.5 (14.8)	131.6 (15.2)	131.3 (14.3)	129.9 (14.2)	130.8 (14.7)
DBP (mm Hg), mean (SD)	78.6 (8.8)	78.7 (9.2)	80.1 (8.6)	79.1 (9.2)	79.1 (8.9)
HR (beats per minute), mean (SD)	74.1 (9.4)	74.8 (9.1)	75.2 (9.6)	74.9 (9.8)	74.7 (9.5)
ALT (U/L), mean (SD)^c	32.8 (19.2)	32.2 (19.1)	33.4 (19.6)	34.2 (21.8)	33.1 (19.9)
AST (U/L), mean (SD)^d	26.9 (12.8)	25.9 (12.7)	26.2 (11.2)	26.4 (12.2)	26.3 (12.2)
Lipids (mg/dL), mean (SD)
Total cholesterol	176.7 (42.3)	178.3 (43.4)	177.2 (41.7)	184.9 (43.2)	179.3 (42.7)
LDL-C	98.7 (34.7)	99.5 (37.2)	99.2 (34.5)	104.3 (37.9)	100.4 (36.0)
HDL-C	43.9 (11.85)	44.2 (11.54)	44.9 (12.32)	45.2 (12.52)	44.5 (12.1)
Triglycerides	183.0 (147.1)	184.8 (147.0)	175.5 (121.6)	190.5 (141.4)	183.5 (139.6)

A1C: glycated hemoglobin; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BMI: body mass index; DBP: diastolic blood pressure; FPG: fasting plasma glucose; HDL-C: high-density lipoprotein cholesterol; HR: heart rate; LDL-C: low-density lipoprotein cholesterol; SBP: systolic blood pressure; SD: standard deviation; ^aRange of weight change per quartile; ^bValues are presented as incidence of use, with or without other glucose-lowering therapies, unless otherwise indicated; ^cALT normal values: 10 to 40 U/L; ^dAST normal values: 10 to 34 U/L.

Back to article page