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Table 2 Patient demographics and clinical characteristics

From: Association among weight change, glycemic control, and markers of cardiovascular risk with exenatide once weekly: a pooled analysis of patients with type 2 diabetes

Characteristic

Quartile 1 (−37.7 to −4.1 kg) a (n = 455)

Quartile 2 (−4.1 to −2.0 kg) a (n = 458)

Quartile 3 (−2.0 to −0.1 kg) a (n = 450)

Quartile 4 (−0.1 to +21.3 kg) a (n = 455)

Total (N = 1830)

Male, n (%)

223 (49.0)

249 (54.4)

257 (57.1)

283 (62.2)

1015 (55.5)

Age (y), mean (SD)

56 (9)

57 (10)

55 (10)

54 (11)

55 (10)

Known diabetes duration (y), mean (SD)

7 (6)

7 (6)

7 (6)

6 (5)

7 (6)

Race, n (%)

     

  White

320 (70.3)

284 (62.0)

245 (54.4)

251 (55.2)

1104 (60.3)

  Black

8 (1.8)

9 (2.0)

14 (3.1)

16 (3.5)

48 (2.6)

  Hispanic

32 (7.0)

36 (7.9)

34 (7.6)

42 (9.2)

147 (8.0)

  Asian

89 (19.6)

123 (26.9)

153 (34.0)

142 (31.2)

511 (27.9)

  Other

6 (1.3)

6 (2.6)

4 (0.9)

4 (0.9)

20 (1.1)

Glucose-lowering background treatment, n (%)b

     

  Diet and exercise only

72 (15.8)

52 (11.4)

72 (16.0)

90 (19.8)

291 (15.9)

  Insulin

3 (0.7)

1 (0.2)

3 (0.7)

1 (0.2)

8 (0.4)

  Metformin

373 (82.0)

388 (84.7)

355 (78.9)

330 (72.5)

1453 (79.4)

  Thiazolidinedione

22 (4.8)

19 (4.1)

27 (6.0)

32 (7.0)

100 (5.5)

  Sulfonylurea

172 (37.8)

212 (46.3)

207 (46.0)

201 (44.2)

798 (43.6)

A1C (%), mean (SD)

8.3 (1.0)

8.4 (1.0)

8.5 (1.1)

8.7 (1.1)

8.5 (1.1)

FPG (mg/dL), mean (SD)

167.0 (44.2)

170.9 (45.7)

170.9 (46.2)

175.6 (50.8)

171.2 (46.9)

Body weight (kg), mean (SD)

93.7 (21.0)

85.3 (18.9)

85.3 (19.1)

87.7 (21.3)

88.0 (20.4)

BMI (kg/m2)

     

  Mean (SD)

33.3 (5.7)

30.8 (5.6)

30.8 (5.3)

30.9 (5.6)

31.5 (5.6)

  Category

     

  <30

143 (31.4)

222 (48.5)

216 (48.0)

217 (47.7)

801 (43.8)

  ≥30

310 (68.1)

235 (51.3)

228 (50.7)

236 (51.9)

1018 (55.6)

  Missing

2 (0.4)

1 (0.2)

6 (1.3)

2 (0.4)

11 (0.6)

SBP (mm Hg), mean (SD)

130.5 (14.8)

131.6 (15.2)

131.3 (14.3)

129.9 (14.2)

130.8 (14.7)

DBP (mm Hg), mean (SD)

78.6 (8.8)

78.7 (9.2)

80.1 (8.6)

79.1 (9.2)

79.1 (8.9)

HR (beats per minute), mean (SD)

74.1 (9.4)

74.8 (9.1)

75.2 (9.6)

74.9 (9.8)

74.7 (9.5)

ALT (U/L), mean (SD)c

32.8 (19.2)

32.2 (19.1)

33.4 (19.6)

34.2 (21.8)

33.1 (19.9)

AST (U/L), mean (SD)d

26.9 (12.8)

25.9 (12.7)

26.2 (11.2)

26.4 (12.2)

26.3 (12.2)

Lipids (mg/dL), mean (SD)

     

  Total cholesterol

176.7 (42.3)

178.3 (43.4)

177.2 (41.7)

184.9 (43.2)

179.3 (42.7)

  LDL-C

98.7 (34.7)

99.5 (37.2)

99.2 (34.5)

104.3 (37.9)

100.4 (36.0)

  HDL-C

43.9 (11.85)

44.2 (11.54)

44.9 (12.32)

45.2 (12.52)

44.5 (12.1)

  Triglycerides

183.0 (147.1)

184.8 (147.0)

175.5 (121.6)

190.5 (141.4)

183.5 (139.6)

  1. A1C: glycated hemoglobin; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BMI: body mass index; DBP: diastolic blood pressure; FPG: fasting plasma glucose; HDL-C: high-density lipoprotein cholesterol; HR: heart rate; LDL-C: low-density lipoprotein cholesterol; SBP: systolic blood pressure; SD: standard deviation; aRange of weight change per quartile; bValues are presented as incidence of use, with or without other glucose-lowering therapies, unless otherwise indicated; cALT normal values: 10 to 40 U/L; dAST normal values: 10 to 34 U/L.
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Cardiovascular Diabetology

ISSN: 1475-2840