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Table 2 Patient demographics and clinical characteristics

From: Association among weight change, glycemic control, and markers of cardiovascular risk with exenatide once weekly: a pooled analysis of patients with type 2 diabetes

Characteristic Quartile 1 (−37.7 to −4.1 kg) a (n = 455) Quartile 2 (−4.1 to −2.0 kg) a (n = 458) Quartile 3 (−2.0 to −0.1 kg) a (n = 450) Quartile 4 (−0.1 to +21.3 kg) a (n = 455) Total (N = 1830)
Male, n (%) 223 (49.0) 249 (54.4) 257 (57.1) 283 (62.2) 1015 (55.5)
Age (y), mean (SD) 56 (9) 57 (10) 55 (10) 54 (11) 55 (10)
Known diabetes duration (y), mean (SD) 7 (6) 7 (6) 7 (6) 6 (5) 7 (6)
Race, n (%)      
  White 320 (70.3) 284 (62.0) 245 (54.4) 251 (55.2) 1104 (60.3)
  Black 8 (1.8) 9 (2.0) 14 (3.1) 16 (3.5) 48 (2.6)
  Hispanic 32 (7.0) 36 (7.9) 34 (7.6) 42 (9.2) 147 (8.0)
  Asian 89 (19.6) 123 (26.9) 153 (34.0) 142 (31.2) 511 (27.9)
  Other 6 (1.3) 6 (2.6) 4 (0.9) 4 (0.9) 20 (1.1)
Glucose-lowering background treatment, n (%)b      
  Diet and exercise only 72 (15.8) 52 (11.4) 72 (16.0) 90 (19.8) 291 (15.9)
  Insulin 3 (0.7) 1 (0.2) 3 (0.7) 1 (0.2) 8 (0.4)
  Metformin 373 (82.0) 388 (84.7) 355 (78.9) 330 (72.5) 1453 (79.4)
  Thiazolidinedione 22 (4.8) 19 (4.1) 27 (6.0) 32 (7.0) 100 (5.5)
  Sulfonylurea 172 (37.8) 212 (46.3) 207 (46.0) 201 (44.2) 798 (43.6)
A1C (%), mean (SD) 8.3 (1.0) 8.4 (1.0) 8.5 (1.1) 8.7 (1.1) 8.5 (1.1)
FPG (mg/dL), mean (SD) 167.0 (44.2) 170.9 (45.7) 170.9 (46.2) 175.6 (50.8) 171.2 (46.9)
Body weight (kg), mean (SD) 93.7 (21.0) 85.3 (18.9) 85.3 (19.1) 87.7 (21.3) 88.0 (20.4)
BMI (kg/m2)      
  Mean (SD) 33.3 (5.7) 30.8 (5.6) 30.8 (5.3) 30.9 (5.6) 31.5 (5.6)
  Category      
  <30 143 (31.4) 222 (48.5) 216 (48.0) 217 (47.7) 801 (43.8)
  ≥30 310 (68.1) 235 (51.3) 228 (50.7) 236 (51.9) 1018 (55.6)
  Missing 2 (0.4) 1 (0.2) 6 (1.3) 2 (0.4) 11 (0.6)
SBP (mm Hg), mean (SD) 130.5 (14.8) 131.6 (15.2) 131.3 (14.3) 129.9 (14.2) 130.8 (14.7)
DBP (mm Hg), mean (SD) 78.6 (8.8) 78.7 (9.2) 80.1 (8.6) 79.1 (9.2) 79.1 (8.9)
HR (beats per minute), mean (SD) 74.1 (9.4) 74.8 (9.1) 75.2 (9.6) 74.9 (9.8) 74.7 (9.5)
ALT (U/L), mean (SD)c 32.8 (19.2) 32.2 (19.1) 33.4 (19.6) 34.2 (21.8) 33.1 (19.9)
AST (U/L), mean (SD)d 26.9 (12.8) 25.9 (12.7) 26.2 (11.2) 26.4 (12.2) 26.3 (12.2)
Lipids (mg/dL), mean (SD)      
  Total cholesterol 176.7 (42.3) 178.3 (43.4) 177.2 (41.7) 184.9 (43.2) 179.3 (42.7)
  LDL-C 98.7 (34.7) 99.5 (37.2) 99.2 (34.5) 104.3 (37.9) 100.4 (36.0)
  HDL-C 43.9 (11.85) 44.2 (11.54) 44.9 (12.32) 45.2 (12.52) 44.5 (12.1)
  Triglycerides 183.0 (147.1) 184.8 (147.0) 175.5 (121.6) 190.5 (141.4) 183.5 (139.6)
  1. A1C: glycated hemoglobin; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BMI: body mass index; DBP: diastolic blood pressure; FPG: fasting plasma glucose; HDL-C: high-density lipoprotein cholesterol; HR: heart rate; LDL-C: low-density lipoprotein cholesterol; SBP: systolic blood pressure; SD: standard deviation; aRange of weight change per quartile; bValues are presented as incidence of use, with or without other glucose-lowering therapies, unless otherwise indicated; cALT normal values: 10 to 40 U/L; dAST normal values: 10 to 34 U/L.
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Cardiovascular Diabetology

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