Median changes in ALT and AST, by end-point body weight change quartiles. (A) ALT. (B) AST. ALT, alanine aminotransferase; AST, aspartate aminotransferase. The central line represents the median (also labelled above the plot), the box encloses the 25th to 75th percentiles of the distribution, and the outer bars are drawn to the 10th and 90th percentiles.