Table 4 Changes in fasting serum lipids and ketone bodies at day 29

Total cholesterol, mg/dl

Baseline

212.8 (7.7)

200.1 (8.4)

208.7 (9.1)

Change from baseline at day 29

−0.8 (3.6)

3.2 (3.7)

1.1 (3.7)

 Difference vs placebo (95% CI)

4.0 (−6.6, 14.6)

1.9 (−8.6, 12.3)

 p-value

0.455

0.722

HDL-cholesterol, mg/dl

Baseline

46.8 (2.2)

47.6 (2.8)

46.8 (2.8)

Change from baseline at day 29

0.1 (1.2)

4.7 (1.3)

7.4 (1.3)

 Difference vs placebo (95% CI)

4.5 (1.0, 8.1)

7.2 (3.7, 10.8)

 p-value

0.014

<0.001

LDL-cholesterol, mg/dl

Baseline

128.7 (6.3)

124.9 (8.4)

130.5 (8.5)

Change from baseline at day 29

−1.3 (3.2)

3.4 (3.3)

4.3 (3.3)

 Difference vs placebo (95% CI)

4.7 (−4.6, 14.0)

5.7 (−3.5, 14.8)

 p-value

0.314

0.221

Triglycerides, mg/dl*

Baseline

159.6 (51.0)

131.5 (34.9)

142.2 (48.0)

Relative change from baseline at day 29

1.0 (0.9, 1.1)

0.8 (0.7, 0.9)

0.7 (0.6, 0.8)

 Difference vs placebo (95% CI)

0.8 (0.7, 1.0)

0.7 (0.6, 0.8)

 p-value

0.037

<0.001

Free fatty acids, mg/dl

Baseline

10.8 (0.8)

9.6 (0.7)

9.3 (0.6)

Change from baseline at day 29

3.1 (0.8)

4.8 (0.8)

7.4 (0.8)

 Difference vs placebo (95% CI)

1.7 (−0.6, 4.1)

4.3 (2.0, 6.7)

 p-value

0.149

<0.001

Ketone bodies, μmol/l

Baseline

86.8 (10.2)

78.1 (12.0)

69.4 (10.8)

Change from baseline at day 29

−12.2 (44.0)

139.5 (44.7)

408.0 (45.5)

 Difference vs placebo (95% CI)

151.7 (24.4, 279.0)

420.2 (293.3, 547.2)

 p-value

0.021

<0.001