| |
Placebo (n = 20)
|
Empagliflozin 10 mg (n = 20)
|
Empagliflozin 25 mg (n = 19)
|
|---|
|
Fasting state, pg/ml
| | | |
|
Baseline
|
197.8 (27.0)
|
194.6 (29.4)
|
146.5 (18.5)
|
|
Change from baseline at day 28
|
40.6 (22.6)
|
−48.1 (23.3)
|
−33.5 (23.7)
|
|
Difference vs placebo (95% CI)
| |
−88.6 (−154.6, −22.7)
|
−74.0 (−139.8, −8.2)
|
|
p-value
| |
0.010
|
0.028
|
|
In 24 hours after drug administration, pg/ml
| | | |
|
Baseline
|
115.5 (11.0)
|
138.3 (20.6)
|
148.6 (21.7)
|
|
Change from baseline at day 28
|
−3.7 (10.3)
|
−28.4 (10.4)
|
−46.8 (10.6)
|
|
Difference vs placebo (95% CI)
| |
−24.7 (−54.5, 5.2)
|
−43.1 (−72.9, −13.3)
|
|
p-value
| |
0.103
|
0.006
|
- Baseline data are mean (standard error [SE]), change from baseline data are adjusted mean (SE) based on analysis of covariance (ANCOVA) in the full analysis set.
