Table 3 Changes in urinary excretion of 8-iso-PGF2α at day 28
|  | Placebo (n = 20) | Empagliflozin 10 mg (n = 20) | Empagliflozin 25 mg (n = 19) |
|---|---|---|---|
Fasting state, pg/ml | Â | Â | Â |
Baseline | 197.8 (27.0) | 194.6 (29.4) | 146.5 (18.5) |
Change from baseline at day 28 | 40.6 (22.6) | −48.1 (23.3) | −33.5 (23.7) |
 Difference vs placebo (95% CI) |  | −88.6 (−154.6, −22.7) | −74.0 (−139.8, −8.2) |
 p-value |  | 0.010 | 0.028 |
In 24Â hours after drug administration, pg/ml | Â | Â | Â |
Baseline | 115.5 (11.0) | 138.3 (20.6) | 148.6 (21.7) |
Change from baseline at day 28 | −3.7 (10.3) | −28.4 (10.4) | −46.8 (10.6) |
 Difference vs placebo (95% CI) |  | −24.7 (−54.5, 5.2) | −43.1 (−72.9, −13.3) |
 p-value |  | 0.103 | 0.006 |