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Table 2 Phenotypic characteristics of Tibetan minipigs fed a control (Ctr) or high-fat/cholesterol atherogenic (HFC) diet

From: Involvement of peroxisome proliferator-activated receptors in cardiac and vascular remodeling in a novel minipig model of insulin resistance and atherosclerosis induced by consumption of a high-fat/cholesterol diet

Parameters Ctr group HFC group P- value
Starting body weight (kg) 16.73 ± 0.72 16.30 ± 0.54 NS
End body weight (kg) 33.43 ± 1.29 49.40 ± 1.07b <0.0001
End body mass index (kg/m2) 41.98 ± 1.35 57.05 ± 1.93b 0.0002
Total cholesterol (mg/dL) 96.08 ± 7.96 406.60 ± 42.26b 0.0006
HDL-C (mg/dL) 33.77 ± 3.42 120.60 ± 5.34b <0.0001
LDL-C (mg/dL) 42.76 ± 5.55 186.30 ± 21.93b 0.0009
Triglycerides (mg/dL) 23.61 ± 2.31 25.38 ± 3.69 NS
Free fatty acids (nmol/L) 0.51 ± 0.01 0.61 ± 0.01b 0.0002
Fasting blood glucose (mmol/L) 4.64 ± 0.10 5.47 ± 0.20b 0.0076
Fasting insulin (mU/L) 18.05 ± 0.74 21.61 ± 0.49b 0.0083
HOMA-IR 3.71 ± 0.09 5.24 ± 0.17b <0.0001
  1. Ctr: control group animals (n = 4); HFC: high-fat/cholesterol atherogenic diet animals (n = 6); HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; HOMA-IR: homeostasis model assessment of insulin resistance. Values are shown as mean ± SEM. a, P < 0.05 and b, P < 0.01 versus control group. NS: not significant.