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Figure 8 | Cardiovascular Diabetology

Figure 8

From: Involvement of peroxisome proliferator-activated receptors in cardiac and vascular remodeling in a novel minipig model of insulin resistance and atherosclerosis induced by consumption of a high-fat/cholesterol diet

Figure 8

Schematic representation of insulin resistance and atherosclerosis mechanisms in Tibetan minipig. Conditions were induced by feeding with a high-fat/cholesterol diet in minipigs with chronic myocardial ischemia. PPARs, peroxisome proliferator-activated receptors; NF-ĸB, nuclear factor ĸB; IL-1β, interleukin 1 beta; and TNF-α: tumor necrosis factor alpha; CRP, C-reactive protein. Arrows pointing up or down indicate statistically significant increases or decreases (P < 0.05). Lack of arrows indicates no alteration. The heart and vessel figures were prepared using a template on the Servier Medical Art website (http:// www.servier.fr/servier-medical-art).

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Cardiovascular Diabetology

ISSN: 1475-2840