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Table 4 GENEDIAB cohort: Plasma EC-SOD, AOPP and Isoprostane concentrations at baseline by SOD3 genotypes

From: Plasma extracellular superoxide dismutase concentration, allelic variations in the SOD3 gene and risk of myocardial infarction and all-cause mortality in people with type 1 and type 2 diabetes

  EC-SOD (ng/ml) AOPP (μmol/l) Isoprostane (ng/ml)
rs2284659
GG (n) 165 ± 17 (165) 66 ± 3 (156) 1.98 ± 0.11 (162)
GT (n) 230 ± 16 (172) 64 ± 3 (171) 1.92 ± 0.11 (181)
TT (n) 222 ± 25 (74) 55 ± 4 (73) 1.98 ± 0.16 (73)
p 0.007 0.02 0.90
rs1799895
CC (n) 169 ± 6 (400) 64 ± 2 (390) 1.93 ± 0.10 (407)
CG (n) 1156 ± 32 (12) 52 ± 10 (12) 1.78 ± 0.34 (12)
p <0.0001 0.34 0.41
  1. Results expressed as mean ± SEM. Statistics are ANCOVA adjusted for sex, age, BMI, systolic blood pressure and eGFR (EC-SOD), for sex, age, total cholesterol concentration, and use of ACE inhibitors (AOPP), and for sex, age, diastolic blood pressure, and use of lipid lowering drugs (isoprostane). p ≤ 0.01 is significant.