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Table 4 GENEDIAB cohort: Plasma EC-SOD, AOPP and Isoprostane concentrations at baseline by SOD3 genotypes

From: Plasma extracellular superoxide dismutase concentration, allelic variations in the SOD3 gene and risk of myocardial infarction and all-cause mortality in people with type 1 and type 2 diabetes

 

EC-SOD (ng/ml)

AOPP (μmol/l)

Isoprostane (ng/ml)

rs2284659

GG (n)

165 ± 17 (165)

66 ± 3 (156)

1.98 ± 0.11 (162)

GT (n)

230 ± 16 (172)

64 ± 3 (171)

1.92 ± 0.11 (181)

TT (n)

222 ± 25 (74)

55 ± 4 (73)

1.98 ± 0.16 (73)

p

0.007

0.02

0.90

rs1799895

CC (n)

169 ± 6 (400)

64 ± 2 (390)

1.93 ± 0.10 (407)

CG (n)

1156 ± 32 (12)

52 ± 10 (12)

1.78 ± 0.34 (12)

p

<0.0001

0.34

0.41

  1. Results expressed as mean ± SEM. Statistics are ANCOVA adjusted for sex, age, BMI, systolic blood pressure and eGFR (EC-SOD), for sex, age, total cholesterol concentration, and use of ACE inhibitors (AOPP), and for sex, age, diastolic blood pressure, and use of lipid lowering drugs (isoprostane). p ≤ 0.01 is significant.
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Cardiovascular Diabetology

ISSN: 1475-2840