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Table 2 GENEDIAB/GENESIS pooled study: genotype frequency of SOD3 variants by the incidence of myocardial infarction and all-cause mortality during follow-up

From: Plasma extracellular superoxide dismutase concentration, allelic variations in the SOD3 gene and risk of myocardial infarction and all-cause mortality in people with type 1 and type 2 diabetes

 

Myocardial Infarction during follow-up

All-cause mortality

No

Yes

HR (95% C.I.)

p

No

Yes

HR (95% C.I.)

p

rs2284659

GG

0.413 (268)

0.500 (22)

0.45 (0.25 – 0.77)

0.003

0.412 (265)

0.413 (26)

0.44 (0.21 – 0.73)

0.0006*

GT

0.456 (297)

0.386 (17)

  

0.448 (289)

0.524 (33)

  

TT

0.131 (85)

0.114 (5)

  

0.140 (90)

0.063 (4)

  

MAF

0.359

0.307

  

0.364

0.325

  

rs1799895

CC

0.983 (638)

1.000 (42)

-

**

0.983 (628)

1.000 (65)

-

**

CG

0.017 (11)

0 (0)

  

0.017 (11)

0.000 (0)

  

GG

0

0 (0)

  

0

0 (0)

  

MAF

0.008

0

  

0.009

0

  

rs2695234

GG

0.861 (566)

0.930 (40)

0.54 (0.09 – 1.70)

0.34

0.858 (558)

0.922 (59)

0.65 (0.32 – 1.08)

0.10

GA

0.130 (85)

0.047 (2)

  

0.133 (86)

0.062 (4)

  

AA

0.009 (6)

0.023 (1)

  

0.009 (6)

0.016 (1)

  

MAF

0.074

0.047

  

0.076

0.047

  

rs17552548

AA

0.894 (575)

0975 (39)

-

**

0.904 (574)

0.857 (54)

1.47 (0.99 – 2.06)

0.06

GA

0.104 (67)

0.025 (1)

  

0.094 (60)

0.143 (9)

  

GG

0.002 (1)

0 (0)

  

0.002 (1)

0 (0)

  

MAF

0.054

0.013

  

0.049

0.071

  

rs758946

TT

0.857 (553)

0.930 (40)

0.49 (0.08 – 1.52)

0.25

0.853 (544)

0.936 (59)

0.68 (0.33 – 1.13)

0.15

TC

0.135 (87

0.047 (2)

  

0.138 (88)

0.064 (4)

  

CC

0.008 (5)

0.023 (1)

  

0.009 (6)

0 (0)

  

MAF

0.075

0.047

  

0.078

0.032

  

rs2270224

GG

0.270 (169)

0.136 (6)

1.12 (0.65 – 1.91)

0.68

0.257 (158)

0.303 (20)

0.75 (0.50 – 1.04)

0.09*

GA

0.483 (304)

0.682 (30)

  

0.495 (306)

0.530 (35)

  

AA

0.247 (155)

0.182 (8)

  

0.248 (153)

0.167 (11)

  

MAF

0.489

0.523

  

0.496

0.432

  
  1. Genotype data expressed as frequency and (number of cases). SNPs are sorted in 5’ to 3’ order. Hazards ratio for the minor allele in a dominant or recessive* model, determined in Cox proportional hazards survival regressive model, adjusted for sex, age, duration of diabetes, blood pressure, HbA1c, UAE, eGFR, use of antihypertensive and lipid lowering medications, tobacco smoking and cohort membership. p ≤ 0.01 is significant. MAF: minor allele frequency. **Statistics not computed due to low MAF (<0.02).