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Table 2 GENEDIAB/GENESIS pooled study: genotype frequency of SOD3 variants by the incidence of myocardial infarction and all-cause mortality during follow-up

From: Plasma extracellular superoxide dismutase concentration, allelic variations in the SOD3 gene and risk of myocardial infarction and all-cause mortality in people with type 1 and type 2 diabetes

  Myocardial Infarction during follow-up All-cause mortality
No Yes HR (95% C.I.) p No Yes HR (95% C.I.) p
rs2284659
GG 0.413 (268) 0.500 (22) 0.45 (0.25 – 0.77) 0.003 0.412 (265) 0.413 (26) 0.44 (0.21 – 0.73) 0.0006*
GT 0.456 (297) 0.386 (17)    0.448 (289) 0.524 (33)   
TT 0.131 (85) 0.114 (5)    0.140 (90) 0.063 (4)   
MAF 0.359 0.307    0.364 0.325   
rs1799895
CC 0.983 (638) 1.000 (42) - ** 0.983 (628) 1.000 (65) - **
CG 0.017 (11) 0 (0)    0.017 (11) 0.000 (0)   
GG 0 0 (0)    0 0 (0)   
MAF 0.008 0    0.009 0   
rs2695234
GG 0.861 (566) 0.930 (40) 0.54 (0.09 – 1.70) 0.34 0.858 (558) 0.922 (59) 0.65 (0.32 – 1.08) 0.10
GA 0.130 (85) 0.047 (2)    0.133 (86) 0.062 (4)   
AA 0.009 (6) 0.023 (1)    0.009 (6) 0.016 (1)   
MAF 0.074 0.047    0.076 0.047   
rs17552548
AA 0.894 (575) 0975 (39) - ** 0.904 (574) 0.857 (54) 1.47 (0.99 – 2.06) 0.06
GA 0.104 (67) 0.025 (1)    0.094 (60) 0.143 (9)   
GG 0.002 (1) 0 (0)    0.002 (1) 0 (0)   
MAF 0.054 0.013    0.049 0.071   
rs758946
TT 0.857 (553) 0.930 (40) 0.49 (0.08 – 1.52) 0.25 0.853 (544) 0.936 (59) 0.68 (0.33 – 1.13) 0.15
TC 0.135 (87 0.047 (2)    0.138 (88) 0.064 (4)   
CC 0.008 (5) 0.023 (1)    0.009 (6) 0 (0)   
MAF 0.075 0.047    0.078 0.032   
rs2270224
GG 0.270 (169) 0.136 (6) 1.12 (0.65 – 1.91) 0.68 0.257 (158) 0.303 (20) 0.75 (0.50 – 1.04) 0.09*
GA 0.483 (304) 0.682 (30)    0.495 (306) 0.530 (35)   
AA 0.247 (155) 0.182 (8)    0.248 (153) 0.167 (11)   
MAF 0.489 0.523    0.496 0.432   
  1. Genotype data expressed as frequency and (number of cases). SNPs are sorted in 5’ to 3’ order. Hazards ratio for the minor allele in a dominant or recessive* model, determined in Cox proportional hazards survival regressive model, adjusted for sex, age, duration of diabetes, blood pressure, HbA1c, UAE, eGFR, use of antihypertensive and lipid lowering medications, tobacco smoking and cohort membership. p ≤ 0.01 is significant. MAF: minor allele frequency. **Statistics not computed due to low MAF (<0.02).