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Table 1 GENEDIAB/GENESIS pooled study: Characteristics of participants at baseline by the incidence of myocardial infarction and all-cause mortality during follow-up

From: Plasma extracellular superoxide dismutase concentration, allelic variations in the SOD3 gene and risk of myocardial infarction and all-cause mortality in people with type 1 and type 2 diabetes

  Myocardial Infarction during follow-up All-cause mortality
No Yes p No Yes p
N 735 49   712 72  
Male sex (%) 53.8 69.4 0.03 53.7 70.8 0.005
Age (years) 42.6 ± 11.0 52.3 ± 12.5 <0.0001 42.7 ± 11.1 49.5 ± 12.6 <0.0001
Duration of diabetes (years) 27.1 ± 9.0 33.3 ± 11.6 0.0004 27.2 ± 9.1 31.3 ± 10.6 0.004
Body mass index (kg/m2) 24.2 ± 3.5 24.9 ± 3.7 0.24 24.4 ± 3.5 23.6 ± 3.8 0.07
Systolic blood pressure (mmHg) 134 ± 19 144 ± 21 0.0007 134 ± 19 142 ± 18 0.0005
Diastolic blood pressure (mmHg) 77 ± 11 80 ± 11 0.07 76 ± 11 80 ± 10 0.004
HbA1c (%) and (mmol/mol) 8.5 ± 1.5 (70 ± 16) 8.9 ± 1.5 (74 ± 16) 0.08 8.5 ± 1.4 (69 ± 15) 9.4 ± 2.3 (79 ± 25) <0.0001
Urinary albumin excretion (mg/l) 21 (177) 43 (836) 0.22 19 (157) 188 (900) <0.0001
eGFR (ml/min) 86 ± 47 70 ± 31 0.02 86 ± 46 69 ± 56 <0.0001
Total cholesterol* (mmol/l) 5.67 ± 1.51 5.91 ± 1.07 0.28 5.65 ± 1.42 5.76 ± 1.67 0.97
Lipids lowering therapy (%) 7.9 16.3 0.04 8.3 11.1 0.41
Tobacco smoking (%) 42.0 47.9 0.42 41.2 59.2 0.004
Arterial hypertension (%) 60.8 83.7 0.001 60.5 84.7 <0.0001
Previous myocardial infarction (%) 3.8 22.9 <0.0001 3.9 21.1 <0.0001
  1. Results expressed as mean ± SD, except urinary albumin excretion (UAE) expressed as median and interquartile range. Statistics of quantitative parameters are ANOVA performed with log-transformed data, or Wilcoxon test (UAE). eGFR: estimated glomerular filtration rate. *Data available only in the GENEDIAB cohort (n = 247). p < 0.05 is significant.