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Table 3 Association between vascular calcified plaque scores and mortality in DHS participants based on Cox Proportional Hazards regression

From: Prediction of mortality using a multi-bed vascular calcification score in the Diabetes Heart Study

 

Model 1

Model 2

Model 3

All-cause mortality

 

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

CAC

2.02 (1.63-2.52)

2.58 × 10−10

1.87 (1.45-2.41)

1.31 × 10−6

1.76 (1.36-2.27)

2.01 × 10−5

CarCP

1.93 (1.61-2.32)

2.42 × 10−12

1.62 (1.34-1.96)

5.81 × 10−7

1.54 (1.27-1.87)

1.37 × 10−5

AACP

1.72 (1.51-1.97)

3.55 × 10−15

1.45 (1.24-1.69)

2.24 × 10−6

1.39 (1.18-1.62)

5.40 × 10−5

Multi-bed

1.81 (1.57-2.09)

2.22 × 10−16

1.60 (1.36-1.88)

1.72 × 10−8

1.52 (1.29-1.81)

1.13 × 10−6

CVD mortality

CAC

2.24 (1.60-3.13)

2.24 × 10−6

2.01 (1.38-2.93)

0.0003

1.88 (1.29-2.73)

0.001

CarCP

2.20 (1.65-2.94)

6.62 × 10−8

1.76 (1.31-2.36)

0.0002

1.71 (1.27-2.29)

0.0004

AACP

1.91 (1.57-2.32)

1.01 × 10−10

1.53 (1.20-1.95)

0.0006

1.51 (1.19-1.92)

0.0009

Multi-bed

2.00 (1.63-2.46)

2.73 × 10−11

1.71 (1.34-2.18)

1.26 × 10−5

1.67 (1.32-2.13)

2.62 × 10−5

  1. Calcified plaque scores are considered as continuous variables and standardized to compare relative effects.
  2. Model 1: unadjusted; Model 2: adjusted for age and sex; Model 3: adjusted for age, sex, total cholesterol, HDL-cholesterol, smoking, systolic blood pressure, and anti-hypertensive medication use.
  3. CAC: coronary artery calcified plaque; CarCP: carotid artery calcified plaque; AACP – abdominal aortic calcified plaque.