Figure 7

Anakinra attenuates the vascular pro-oxidant and pro-inflammatory environment leading to diabetic endothelial dysfunction. Effect of (A) tempol (100 μmol/L), (B) apocynin (Apo, 10 μmol/L), (C) indomethacin (Indo; 10 μmol/L), or (D) 1400 W (10 μmol/L) on the impairment of the endothelium-dependent relaxations evoked by ACh (0.1 nmol/L to 10 μmol/L) observed in diabetic SD rats, either untreated or receiving anakinra (AK, 160 mg/Kg/dasy during 3 days). Data are expressed as the percentage of the pre-contraction induced with 1 μmol/L NA. The number of segments used for every curve, which were obtained from 3 to 5 animals, as well as the statistical significance are in parenthesis.