Figure 5

Anakinra improves endothelial function in diabetic rats. Effects of treatment with anakinra (AK) (A; 100 mg/Kg/day for 3 days), (B; 100 mg/Kg/day for 7 days), and (C; 160 mg/Kg/day for 3 days) on the endothelium-dependent relaxations to ACh (0.1 nmol/L to 10 μmol/L) in isolated mesenteric arteries from control and two weeks evolution streptozotocin-induced diabetic SD rats. Data are expressed (means ± SE) as the percentage of the previous contraction induced with 1 μmol/L NA. The number of segments used for every curve, which were obtained from 4 to 10 animals, as well as the statistical significance are in parenthesis.