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Table 2 Effects of linagliptin on 24-hr-food intake, water intake, urine volume, and urinary electrolyte excretions of high-salt loaded DS rats at 1 week and 3 weeks after initiation of linagliptin treatment

From: DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure

  1 wk after the treatment 3 wk after the treatment
Normal Na Veh Lin Normal Na Veh Lin
Food intake (g/day) 24.0 ± 2.0 24.3 ± 1.1 22.3 ± 0.6 28.2 ± 1.8# 22.2 ± 1.5 22.8 ± 0.9
Water intake (ml/day) 19.7 ± 5.2* 84.3 ± 5.9 84.9 ± 4.0 22.8 ± 3.3* 81.3 ± 3.6 81.8 ± 3.4
Urine volume (g/day) 13.5 ± 4.4* 68.6 ± 3.8 65.1 ± 2.6 14.2 ± 1.8* 72.4 ± 3.7 70.4 ± 2.9
Urinary Na (mEq/day) 0.5 ± 0.03* 28.7 ± 1.1 28.7 ± 0.6 0.4 ± 0.03* 29.0 ± 1.0 29.0 ± 1.2
Urinary Cl (mEq/day) 0.6 ± 0.02* 28.4 ± 1.1 28.5 ± 0.7 0.6 ± 0.04* 28.4 ± 0.9 26.6 ± 2.6
Urinary K (mEq/day) 2.9 ± 0.2* 4.0 ± 0.2 4.0 ± 0.1 3.3 ± 0.1# 3.9 ± 0.1 4.0 ± 0.2
  1. Abbreviations used are the same as in Table 1. Values are the means ± SEM (n = 7-11). Statistical analysis was performed by one-factor analysis of variation (ANOVA) followed by post hoc Fisher’s protected least significant difference test.
  2. #P < 0.05, *P < 0.01 vs Veh.