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Table 2 Effects of linagliptin on 24-hr-food intake, water intake, urine volume, and urinary electrolyte excretions of high-salt loaded DS rats at 1 week and 3 weeks after initiation of linagliptin treatment

From: DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure

 

1 wk after the treatment

3 wk after the treatment

Normal Na

Veh

Lin

Normal Na

Veh

Lin

Food intake (g/day)

24.0 ± 2.0

24.3 ± 1.1

22.3 ± 0.6

28.2 ± 1.8#

22.2 ± 1.5

22.8 ± 0.9

Water intake (ml/day)

19.7 ± 5.2*

84.3 ± 5.9

84.9 ± 4.0

22.8 ± 3.3*

81.3 ± 3.6

81.8 ± 3.4

Urine volume (g/day)

13.5 ± 4.4*

68.6 ± 3.8

65.1 ± 2.6

14.2 ± 1.8*

72.4 ± 3.7

70.4 ± 2.9

Urinary Na (mEq/day)

0.5 ± 0.03*

28.7 ± 1.1

28.7 ± 0.6

0.4 ± 0.03*

29.0 ± 1.0

29.0 ± 1.2

Urinary Cl (mEq/day)

0.6 ± 0.02*

28.4 ± 1.1

28.5 ± 0.7

0.6 ± 0.04*

28.4 ± 0.9

26.6 ± 2.6

Urinary K (mEq/day)

2.9 ± 0.2*

4.0 ± 0.2

4.0 ± 0.1

3.3 ± 0.1#

3.9 ± 0.1

4.0 ± 0.2

  1. Abbreviations used are the same as in Table 1. Values are the means ± SEM (n = 7-11). Statistical analysis was performed by one-factor analysis of variation (ANOVA) followed by post hoc Fisher’s protected least significant difference test.
  2. #P < 0.05, *P < 0.01 vs Veh.
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Cardiovascular Diabetology

ISSN: 1475-2840