Figure 5

Effect of linagliptin on vascular relaxation induced by acetylcholine (A) and SNP (B), vascular superoxide (C), and vascular p22phox (D) of high salt-loaded DS rats. Each value represents mean ± SEM (n = 7 in Normal Na, n = 9-11 in Veh, n = 11 in Lin). Abbreviations used are the same as in Figure 1. NS, not significant between groups. Upper panels in (C) and (D) indicate representative photomicrographs of aortic sections stained with dihydroethidium and representative western blot bands, respectively.