Table 1 Analysis of transcriptome of PACs isolated from bone marrow of wild type (WT) or diabetic (db/db) mice and cultured in vitro for 9 days

Oxidative stress and cytoprotection

WT

db / db

WT

db / db

Nox4 (NOX4)

148 ± 20.3

245 ± 15.2*

153 ± 25.0

302 ± 123.8^#0.082

Cyba (p22phox)

29331 ± 1383.1

35829 ± 1277.4**

28248 ± 2195.8

34380 ± 5610.4

Prkcd (PKCδ)

3134 ± 75.8

3698 ± 286.6*

3667 ± 518.5

3965 ± 413.3

Chst1 (GST-1)

6979 ± 411.2

4412 ± 341.3**

8339 ± 562.9

5774 ± 374.8*^#

Mgst3 (GST III)

3388 ± 453.1

1741 ± 100.7*

4076 ± 590.9

2563 ± 342.6* 0.070; ^#0.091

Gpx4 (GPX4)

7819 ± 354

6920 ± 423.3*

8394 ± 76.9^#

7599 ± 614.9* 0.076; ^#0.099

Inflammation

WT

db / db

WT

db/db

Tnfrsf1a (TNFR-1)

1259 ± 68.7

1447 ± 124.7* 0.051

1103 ± 298.5

1147 ± 82.5^#

Csf3r (G-CSF3R)

188 ± 6.7

214.9 ± 9.5*

209 ± 7.9

237 ± 36.1

Cxcl16 (CXCL16)

2328 ± 215.3

3194 ± 403.5*

2464 ± 319.2

2972 ± 535.2

Selplg (P-selectin ligand)

1930 ± 219.1

2758 ± 324.4*

2737 ± 822.8

3214 ± 311.0^# 0.077

Extracellular matrix remodeling

WT

db / db

WT

db / db

Mmp2 (MMP-2)

2825 ± 395.2

6498 ± 1373.3*

2567 ± 900.6

6454 ± 905.8**

Mmp9 (MMP-9)

1906 ± 1005.0

7554 ± 4171.7* 0.069

1713 ± 637.0

9625 ± 955.3***

Mmp14 (MMP-14)

5081 ± 513.8

5965 ± 461.9*

5499 ± 518.5

5758 ± 519.5

Mmp23 (MMP-23)

1625 ± 273.8

2127 ± 267.9*

2396 ± 521.2^#0.054

2956 ± 338.2^#

Migration and proliferation

WT

db / db

WT

db / db

Itgam (integrin-α1)

983 ± 254.4

1397 ± 30.8* 0.052

1499 ± 313.8^#0.096

1397 ± 498.6*

Itgb2 (integrin-β2)

354 ± 37.4

438 ± 30.9*

472 ± 76.2^#

587 ± 90.8* 0.085^#

Itgb4 (integrin-β4)

105 ± 11.2

141 ± 4.28*

178 ± 66.0^# 0.096

187 ± 26.7^#

Ngef (NGEF)

163 ± 2.9

104 ± 8.2**

246 ± 36.2^#

140 ± 5.7*^##

Cct2 (CCT2)

166 ± 4.0

139 ± 4.9**

136 ± 11.6^#

145 ± 16.6

Msx1 (MSX-1)

184 ± 18.5

132 ± 13.7**

159 ± 17.8^#0.081

127 ± 1.24*

Cdkl2 (CDKL2)

233 ± 17.3

177 ± 7.4**

205 ± 19.7^#0.066

193 ± 15.9

Areg (AREG)

322 ± 69.7

118 ± 14.5*

290 ± 126.6

155 ± 39.4* 0.099

Mdk (midkin)

236  ± 6.9

313 ± 21.6**

184 ± 3.1^###

300 ± 17.9**

Nos3 (NOS3)

122 ± 3.0

142 ± 5.2**

99 ± 7.4^#

106 ± 6.3^###

Cav1 (caveolin-1)

4279 ± 675.2

2171 ± 242.9*

6460 ± 418.0^##

4889 ± 968.4*^#

Fgf7 (FGF-7)

7073 ± 780.0

5858 ± 795.5* 0.066

5736 ± 403.8^#

5306 ± 958.3

Ang2 (angiogenin)

198 ± 50.5

138 ± 15.9* 0.085

164 ± 42.4

131 ± 6.1

Vegfb (VEGF-B)

1637 ± 107.1

1641 ± 91.4

2396 ± 97.9^###

2195 ± 246.8^#

Vegfc (VEGF-C)

714 ± 69.2

524 ± 91.5*

730 + 111.0

904 ± 331.3^# 0.089

Vegfd (VEGF-D)

791 ± 50.7

499 ± 105.6*

1011 ± 289.9

839 ± 113.8^##