Oxidative stress and cytoprotection
|
WT
|
db
/
db
|
WT
|
db
/
db
|
Nox4 (NOX4)
|
148 ± 20.3
|
245 ± 15.2*
|
153 ± 25.0
|
302 ± 123.8#0.082
|
Cyba (p22phox)
|
29331 ± 1383.1
|
35829 ± 1277.4**
|
28248 ± 2195.8
|
34380 ± 5610.4
|
Prkcd (PKCδ)
|
3134 ± 75.8
|
3698 ± 286.6*
|
3667 ± 518.5
|
3965 ± 413.3
|
Chst1 (GST-1)
|
6979 ± 411.2
|
4412 ± 341.3**
|
8339 ± 562.9
|
5774 ± 374.8*#
|
Mgst3 (GST III)
|
3388 ± 453.1
|
1741 ± 100.7*
|
4076 ± 590.9
|
2563 ± 342.6* 0.070; #0.091
|
Gpx4 (GPX4)
|
7819 ± 354
|
6920 ± 423.3*
|
8394 ± 76.9#
|
7599 ± 614.9* 0.076; #0.099
|
Inflammation
|
WT
|
db
/
db
|
WT
|
db/db
|
Tnfrsf1a (TNFR-1)
|
1259 ± 68.7
|
1447 ± 124.7* 0.051
|
1103 ± 298.5
|
1147 ± 82.5#
|
Csf3r (G-CSF3R)
|
188 ± 6.7
|
214.9 ± 9.5*
|
209 ± 7.9
|
237 ± 36.1
|
Cxcl16 (CXCL16)
|
2328 ± 215.3
|
3194 ± 403.5*
|
2464 ± 319.2
|
2972 ± 535.2
|
Selplg (P-selectin ligand)
|
1930 ± 219.1
|
2758 ± 324.4*
|
2737 ± 822.8
|
3214 ± 311.0# 0.077
|
Extracellular matrix remodeling
|
WT
|
db
/
db
|
WT
|
db
/
db
|
Mmp2 (MMP-2)
|
2825 ± 395.2
|
6498 ± 1373.3*
|
2567 ± 900.6
|
6454 ± 905.8**
|
Mmp9 (MMP-9)
|
1906 ± 1005.0
|
7554 ± 4171.7* 0.069
|
1713 ± 637.0
|
9625 ± 955.3***
|
Mmp14 (MMP-14)
|
5081 ± 513.8
|
5965 ± 461.9*
|
5499 ± 518.5
|
5758 ± 519.5
|
Mmp23 (MMP-23)
|
1625 ± 273.8
|
2127 ± 267.9*
|
2396 ± 521.2#0.054
|
2956 ± 338.2#
|
Migration and proliferation
|
WT
|
db
/
db
|
WT
|
db
/
db
|
Itgam (integrin-α1)
|
983 ± 254.4
|
1397 ± 30.8* 0.052
|
1499 ± 313.8#0.096
|
1397 ± 498.6*
|
Itgb2 (integrin-β2)
|
354 ± 37.4
|
438 ± 30.9*
|
472 ± 76.2#
|
587 ± 90.8* 0.085#
|
Itgb4 (integrin-β4)
|
105 ± 11.2
|
141 ± 4.28*
|
178 ± 66.0# 0.096
|
187 ± 26.7#
|
Ngef (NGEF)
|
163 ± 2.9
|
104 ± 8.2**
|
246 ± 36.2#
|
140 ± 5.7*##
|
Cct2 (CCT2)
|
166 ± 4.0
|
139 ± 4.9**
|
136 ± 11.6#
|
145 ± 16.6
|
Msx1 (MSX-1)
|
184 ± 18.5
|
132 ± 13.7**
|
159 ± 17.8#0.081
|
127 ± 1.24*
|
Cdkl2 (CDKL2)
|
233 ± 17.3
|
177 ± 7.4**
|
205 ± 19.7#0.066
|
193 ± 15.9
|
Areg (AREG)
|
322 ± 69.7
|
118 ± 14.5*
|
290 ± 126.6
|
155 ± 39.4* 0.099
|
Mdk (midkin)
|
236 ± 6.9
|
313 ± 21.6**
|
184 ± 3.1###
|
300 ± 17.9**
|
Nos3 (NOS3)
|
122 ± 3.0
|
142 ± 5.2**
|
99 ± 7.4#
|
106 ± 6.3###
|
Cav1 (caveolin-1)
|
4279 ± 675.2
|
2171 ± 242.9*
|
6460 ± 418.0##
|
4889 ± 968.4*#
|
Fgf7 (FGF-7)
|
7073 ± 780.0
|
5858 ± 795.5* 0.066
|
5736 ± 403.8#
|
5306 ± 958.3
|
Ang2 (angiogenin)
|
198 ± 50.5
|
138 ± 15.9* 0.085
|
164 ± 42.4
|
131 ± 6.1
|
Vegfb (VEGF-B)
|
1637 ± 107.1
|
1641 ± 91.4
|
2396 ± 97.9###
|
2195 ± 246.8#
|
Vegfc (VEGF-C)
|
714 ± 69.2
|
524 ± 91.5*
|
730 + 111.0
|
904 ± 331.3# 0.089
|
Vegfd (VEGF-D)
|
791 ± 50.7
|
499 ± 105.6*
|
1011 ± 289.9
|
839 ± 113.8##
|