Effect of PPARγ agonist rosiglitazone (ROSI, 10 μmol/L, 24 h) and PPARγ antagonist GW9662 (GW, 10 μmol/L, 24 h) on angiogenic potential of PACs and endothelial cells from wild type (WT) or diabetic (db/db) mice. A: Proliferation of PACs. Immunohistochemical detection of PCNA-positive cells. B: Migration of PACs in modified Boyden chambers. C: Formation of cords by PACs seeded on Matrigel, shown as a number of cord junctions per microscopic field. D: Formation of capillaries by endothelial cells from aortic rings isolated from WT or db/db mice and embedded in Matrigel. E: representative pictures showing aortic rings. Each bar represents mean + SEM, expressed as percentage of values for untreated control. N = 4-5, #p < 0.05 versus control.