GW3965 suppressed diabetes-induced inflammatory response in the myocardial tissues. a. Expression of nuclear NF-κB p65 subunit in the myocardial tissue was determined by Western blot (n =5-6). Histone level served as loading control for nuclear protein expression. Results were normalized against histone and converted to fold induction relative to db/+ mice. b-c. TNF- α and IL-1β content in the myocardial tissue was determined by ELISA analysis (n =6-8). **P < 0.01 vs db/+ group; #P < 0.05 or ##P < 0.01 vs db/db group. Abbreviations: GW, GW3965; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B; TNF- α, tumor necrosis factor-α; IL-1β, interleukin-1β.