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Figure 11 | Cardiovascular Diabetology

Figure 11

From: Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice

Figure 11

Effects of empagliflozin on urinary albumin/creatinine ratio (A), glomerular sclerosis (B), glomerular macrophage infiltration (C) and glomerular superoxide (D) of db/db mice. Urinary albumin/creatinine ratio in (A) was measured at 4 and 8 weeks after start of drug treatment. Upper panels in (B), (C), and (D) indicate representative photomicrographs of renal sections stained with PAS, CD68 antibody, and dihydroethidium, respectively. Abbreviations used are the same as in Figure 5. *p < 0.05, *p < 0.01 vs control db/db mice. Values are mean ± SEM (n = 9-11). Bar = 50 μm in (B), (C), and (D).

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