Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance

Du, Tingting; Yuan, Gang; Zhang, Muxun; Zhou, Xinrong; Sun, Xingxing; Yu, Xuefeng

doi:10.1186/s12933-014-0146-3

Cardiovascular Diabetology

Table 2 Multiple linear regression models for predicting homeostatic model assessment

From: Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance

	Men						Women
	Model 1		Model 2		Model 3		Model 1		Model 2		Model 3
	Additional R²	β	Additional R²	β	Additional R²	β	Additional R²	β	Additional R²	β	Additional R²	β
Lipid measures
Ln TC	0.001	0.129^*	0.002	0.168^*	0.002	0.163^†	0.001	0.086	0.004	0.229^†	0.001	0.1
Ln TG	0.027	0.26^†	0.031	0.239^†	0.03	0.268^†	0.022	0.223^†	0.043	0.286^†	0.025	0.237^†
Ln LDL-C	0.001	0.045	0	0.006	0.001	0.066	0.001	0.07^*	0.002	0.099^*	0.001	0.071^*
Ln Non-HD L-C	0.005	0.204^†	0.007	0.230^†	0.007	0.243^†	0.003	0.147^†	0.011	0.264^†	0.004	0.166^†
Ln Apo B	0.003	0.151*	0.004	0.160†	0.004	0.171†	0.006	0.194†	0.014	0.284†	0.006	0.204†
Ln HDL-C	0.009	-0.333^†	0.013	-0.354^†	0.014	-0.373^†	0.005	-0.211^†	0.01	-0.306^†	0.006	-0.238
Ln Apo A-I	0.006	-0.235^†	0.006	-0.237^†	0.007	-0.261^†	0	-0.01	0	-0.005	0	-0.014
Lipid ratios
Ln TC/HDL-C	0.014	0.339^†	0.017	0.355^†	0.018	0.383^†	0.007	0.229^†	0.019	0.370^†	0.008	0.257^†
Ln TG/ HDL-C	0.029	0.212^†	0.033	0.197^†	0.033	0.224^†	0.023	0.170^†	0.045	0.221^†	0.026	0.181^†
Ln LDL-C/HDL-C	0.01	0.160^†	0.016	0.146^†	0.015	0.190^†	0.006	0.157^†	0.012	0.224^†	0.007	0.17^†
Ln Non- HDL-C/HDL-C	0.013	0.227^†	0.016	0.239^†	0.017	0.257^†	0.007	0.163^†	0.019	0.256^†	0.009	0.182^†
Ln Apo B/apo A-I	0.01	0.213^†	0.011	0.221^†	0.013	0.237^†	0.004	0.136^†	0.01	0.204^†	0.005	0.145^†
Visceral adiposity indicators
Ln LAP	0.017	0.141^†	0.021	0.143^†	0.015	0.165^†	0.016	0.147^†	0.033	0.195^†	0.017	0.178^†
Ln VAI	0.031	0.213^†	0.034	0.198^†	0.031	0.217^†	0.021	0.172^†	0.042	0.222^†	0.02	0.173^†
TyG index	0.091	0.390^†	0.089	0.347^†	0.095	0.40^†	0.078	0.359^†	0.107	0.381^†	0.08	0.367^†

*P <0.05. ^†P <0.001.
Model 1 was adjusted for age, rural/urban settings, region, education level, smoking status, alcohol use, body mass index, systolic blood pressure, uric acid, and hs-CRP. Model 2 was adjusted for all the variables in model 1 plus waist circumference.
Model 3 was adjusted for body mass index, rural/urban settings, region, education level, alcohol use, and Framingham Risk Score (low, intermediate, and high).
TC, total cholesterol; TG: triglycerides; LDL-C: low density lipoprotein cholesterol; HDL-C: high density lipoprotein cholesterol; Apo B: apolipoprotein B; Apo A-I: apolipoprotein A1; LAP: lipid accumulation product; VAI: visceral adiposity index; TyG index: the product of triglycerides and fasting glucose.

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