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Table 1 Effects of the short- and continuous-acting GLP-1R agonists (Adapted from reference[13])

From: Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists

 

Short-acting

Continuous-acting

 

Exenatide

Exenatide*

 

Lixisenatide

Liraglutide

  

Albiglutide

  

Dulaglutide

  

Semaglutide

Clinical effects

  

GLP-1R activation

Intermittent

Continuous

HbA1c reduction

+

++

FPG reduction

+

++

PPG reduction

++

+

Gastric emptying deceleration

++

←→

Body weight reduction

++

++

Blood pressure reduction

+

+

Hearth rate increase

←→

+

  1. Abbreviations: GLP-1R glucagon-like peptide-1 receptor, HbA 1c glycated haemoglobin, FPG fasting plasma glucose, PPG postprandial glucose.
  2. *Exenatide once-weekly.