From: Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists
Short-acting | Continuous-acting | |
---|---|---|
Exenatide | Exenatide* | |
Lixisenatide | Liraglutide | |
Albiglutide | ||
Dulaglutide | ||
Semaglutide | ||
Clinical effects | ||
GLP-1R activation | Intermittent | Continuous |
HbA1c reduction | + | ++ |
FPG reduction | + | ++ |
PPG reduction | ++ | + |
Gastric emptying deceleration | ++ | ←→ |
Body weight reduction | ++ | ++ |
Blood pressure reduction | + | + |
Hearth rate increase | ←→ | + |