Figure 5

Effect of cariporide on methylglyoxal-induced microvascular leakage. (A) Representative fluorescence intravital microscopy images (arrows point to the segment of postcapillary venule where permeability index was determined) and (B) means  ± SEM (n = 4) of permeability index analysis of mouse cremasteric postcapillary venules showing the leakage of FITC-conjugated BSA post 1-h i.v. injection and after an intrascrotal injection for 4 h with saline (Control), MG (50 mg/kg) alone or co-treatment with MG and cariporide (20 mg/kg, 1 h prior to MG). * indicates significant difference (p < 0.05) from the absence of MG (Control). # indicates significant difference (p < 0.05) from MG alone.