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Table 2 Circulating levels of lipasin/betatrophin and correlation with other parameters in different studies a

From: A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy

 

References

[22]

[23]

[24]

[50]

[38]

[18]

Conditions

Lean non-diabetic

~300 (pg/ml)

639 (pg/ml)

1203 (pg/ml)b

45.1 (ng/ml)

296.6 (pg/ml)

2.19 (ng/ml)

T1D

~doubled

     

T2D

 

893

 

13.5c

613.1

5.56

Obesity

   

26.9

 

4.42

Postprandial

     

30% increased

Correlation

BMI

   

r = −0.38

 

r s = 0.49

Cholesterol

  

r = 0.65

   

LDL-C

  

r = 0.61

   

HDL-C

   

r = 0.51

  

TAG

   

r = 0.36

  

Glucose

    

r = 0.34

r s = 0.42

HA1c

 

r = 0.48

  

r = 0.29

 

Insulin

   

r = -0.34

r = 0.28

r s = 0.36

Epitoped

N-Ter

N-Ter

N-Ter

NA

N-Ter

C-Ter

  1. aThe differences are statistically significant unless indicated otherwise.
  2. b1643 pg/ml in another cohort.
  3. cObesity and T2D.
  4. dEpitope refers to the epitopes of betatrophin antibodies in corresponding ELISA kits.
  5. Positive correlation with age was noted in references [22],[23],[38]. Betatrophin levels were found to be higher in women (34.1 ng/mL) than in men (21.1 ng/mL) [50]. N-Ter and C-Ter, N-terminal and C-terminal antibodies were used in the ELISA kits manufactured by EIAAB and Phoenix, respectively. The ELISA kit used in [50] is manufactured by Cusabio (Hubei, China), and the antigen is recombinant betatrophin. HA1c, Hemoglobin A1c; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; T1D, type 1 diabetes; T2D, type 2 diabetes; TAG, triacylglyceride.
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Cardiovascular Diabetology

ISSN: 1475-2840