| Unadjusted HR | P | Adjusted HR | P |
---|---|---|---|---|
(95% CI) | (95% CI) | |||
Age | Â | Â | Â | Â |
 18-49 | 1.00 (reference) |  | 1.00 (reference) |  |
 50-64 | 4.49 (4.01-5.03) | <.0001 | 3.17 (2.83-3.56) | <.0001 |
 ≥65 | 16.64 (14.97-18.49) | <.0001 | 8.10 (7.25-9.04) | <.0001 |
Sex | Â | Â | Â | Â |
 Female | 1.00 (reference) |  | 1.00 (reference) |  |
 Male | 1.38 (1.33-1.44) | <.0001 | 1.33 (1.28-1.38) | <.0001 |
Comorbidity | Â | Â | Â | Â |
 Hypertension | 4.39 (4.15-4.63) | <.0001 | 1.27 (1.19-1.35) | <.0001 |
 Congestive heart failure | 5.48 (5.25-5.71) | <.0001 | 2.72 (2.60-2.84) | <.0001 |
 Chronic kidney disease | 1.75 (1.67-1.84) | <.0001 | - - | - - |
 Asthma | 1.96 (1.87-2.05) | <.0001 | 1.10 (1.05-1.15) | <.0001 |
 Hyperthyroidism | 1.00 (0.92-1.10) | 0.9433 |  |  |
 Myocardial infarction | 3.00 (2.73-3.29) | <.0001 | 1.27 (1.15-1.39) | <.0001 |
 Ischemic stroke | 2.27 (2.16-2.39) | <.0001 | 1.06 (1.01-1.12) | 0.0192 |
 Sleep apnea syndrome | 0.95 (0.78-1.16) | 0.6049 |  |  |
 Peripheral arterial disease | 2.52 (2.20-2.90) | <.0001 | 1.22 (1.06-1.40) | 0.0055 |
Medication | Â | Â | Â | Â |
 Metformin | 0.80 (0.75-0.85) | <.0001 | 0.81 (0.76-0.86) | <.0001 |
 Anti-hypertensives* | 6.87 (6.36-7.42) | <.0001 | 3.08 (2.83-3.35) | <.0001 |
 Statin | 1.18 (1.13-1.23) | <.0001 | 0.85 (0.81-0.89) | <.0001 |