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Figure 4 | Cardiovascular Diabetology

Figure 4

From: Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies

Figure 4

HL-1 cells were paced at 4Hz for 24 hours. Figure 4 shows that tachypacing induced intracellular oxidative stress from ROS in atrial myocytes and that metformin reversed this effect. Tachycardia induced myofibril degradation quantified by myosin heavy chain and troponin-I were also rescued by metformin of 1 mM.

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