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Table 2 Heart-rate variability parameters obtained in anesthetized control (db/+) and diabetic (db/db) mice before and after 16 hours fasting

From: Sinoatrial node dysfunction induces cardiac arrhythmias in diabetic mice

  Db/+, fed Db/db, fed Db/+, fasted Db/db, fasted
RR, ms 124 ± 4 131 ± 3 137 ± 4 † 154 ± 4*†
HR, bpm 483 ± 17 458 ± 12 438 ± 11 † 390 ± 10*†
SDRR, ms 4.4 ± 1.0 5.0 ± 0.9 5.3 ± 0.8 6.0 ± 1.6
SD∆RR, ms 2.1 ± 0.3 3.2 ± 0.6 2.8 ± 0.6 4.7 ± 0.7*
pRR6,% 3 ± 4 11 ± 5a 8 ± 3 22 ± 6*
LF Power, μs2 0.9 ± 0.2 0.9 ± 0.4 1.0 ± 0.4 2.5 ± 1.0
HF Power, μs2 2.4 ± 0.6 7.9 ± 3.8 6.1 ± 3.4 15.4 ± 4.3a
LF Power, % 32 ± 4 17 ± 4 17 ± 4 15 ± 5
HF Power, % 67 ± 4 84 ± 4 84 ± 4 86 ± 5
LF/HF 55 ± 11 25 ± 10 24 ± 9 19 ± 4
n 12 12 10 9
  1. Abbreviations: HR (bpm) heart rate in beats per minute, SDRR standard deviation of RR intervals, SD∆RR standard deviation of the difference between successive RR intervals, pRR6 percentage of normal consecutive RR intervals differing by >6 ms, LF power absolute and normalized power contained within the low frequency range (0.15-1.5 Hz), HF power absolute and normalized power contained within the high frequency range (1.5-5.0 Hz). See reference [27]. Two-way ANOVA with a post hoc Bonferroni t test when appropriate. *, P < 0.05 versus db/+ mice; †, P < 0.05 versus fed mice of the same genotype; a, P = 0.063 versus db/+. One mouse was excluded from the db/+, fasted group due to technical difficulties with anesthesia.