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Figure 5 | Cardiovascular Diabetology

Figure 5

From: Nestin downregulation in rat vascular smooth muscle cells represents an early marker of vascular disease in experimental type I diabetes

Figure 5

Endothelial reactivity and nestin expression in type I diabetic rats. (Panel A) Acetylcholine-mediated relaxation of pre-contracted aortic rings was comparable in sham (N = 3) and streptozotocin (STZ, N = 3) induced type I diabetic rats. Nestin expression in the (Panel B) carotid artery and (Panel C) aorta of type I diabetic rats was significantly reduced, whereas CD31 and eNOS levels were unchanged. (*) Denotes P < 0.05 versus sham and protein levels normalized to GAPDH.

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