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Table 1 Univariable logistic regression analysis for the lesion to be the cause of an ACS

From: A score to quantify coronary plaque vulnerability in high-risk patients with type 2 diabetes: an optical coherence tomography study

Parameter ACS (n = 43) SAP (n = 69) OR 95% CI p-value
Clinical:
Age (years) 68.1 ± 9.9 69.6 ± 7.4 0.98 (0.94 - 1.02) ns
Male (n, %) 28 (65.1) 47 (68.1) 0.87 (0.39 - 1.96) ns
BMI (kg/m2) 29.7 ± 5.8 31.5 ± 4.8 0.93 (0.86 - 1.01) 0.081
Hypertension (n, %) 35 (81.4) 60 (87.0) 0.67 (0.23 - 1.86) ns
MAP (mmHg) 93.7 ± 11.5 96.3 ± 13.0 0.98 (0.95 - 1.01) ns
Dyslipidemia (n, %) 26 (60.5) 47 (68.1) 0.72 (0.32 - 1.58) ns
Smoking (n, %) 13 (30.2) 11 (15.9) 2.29 (0.91 - 5.71) 0.077
Family history (n, %) 14 (32.6) 31 (44.9) 0.59 (0.27 - 1.31) ns
Diabetes (years) 12.3 ± 10.5 11.0 ± 9.8 1.01 (0.98 - 1.05) ns
HbA1C (%) 7.78 ± 1.73 7.19 ± 1.45 1.27 (0.98 - 1.65) 0.074
Fasting glukose (mg/dl) 174.8 ± 70.6 164.4 ± 46.7 1.00 (1.00 - 1.01) ns
Total chol (mg/dl) 191.1 ± 43.0 189.8 ± 43.8 1.00 (0.99 - 1.01) ns
LDL-chol (mg/dl) 116.7 ± 36.1 117.0 ± 35.7 1.00 (0.99 - 1.01) ns
HDL-chol (mg/dl) 43.9 ± 14.1 43.9 ± 10.5 1.00 (0.97 - 1.03) ns
Triglyceride (mg/dl) 166.1 ± 92.3 187.1 ± 103.6 1.00 (0.99 - 1.00) ns
CRP (mg/dl) 20.4 ± 30.3 9.1 ± 10.7 1.03 (1.01 - 1.06) 0.016
OCT-derived parameters
MLA (mm2) 1.39 ± 0.76 1.42 ± 0.66 0.94 (0.54 - 1.63) ns
MLD (mm) 1.06 ± 0.26 1.13 ± 0.25 0.30 (0.06 - 1.58) ns
Ref LA (mm2) 6.81 ± 2.36 6.51 ± 2.07 1.06 (0.89 - 1.27) ns
Stenosis length (mm) 9.13 ± 4.22 7.98 ± 5.39 1.05 (0.97 - 1.13) ns
Area stenosis (%) 79.49 ± 7.14 77.34 ± 8.62 1.03 (0.99 - 1.09) ns
Calcified Pl. (n, %) 26 (60.5) 48 (69.6) 0.67 (0.30 - 1.49) ns
Fibrous Pl. (n, %) 33 (76.7) 62 (89.9) 0.37 (0.13 - 1.07) 0.066
Lipid-rich Pl. (n, %) 36 (83.7) 29 (42.0) 7.09 (2.77 - 18.16) <0.001
   TCFA n (%) 32 (88.9) 10 (34.5) 15.20 (4.18 - 55.28) <0.001
   Non-TCFA (n, %) 3 (8.3) 19 (65.5) 0.05 (0.01 - 0.20) <0.001
   Min FCT (10 μm) 5.25 ± 0.94 8.00 ± 2.44 0.39 (0.24 - 0.64) <0.001
   Mean FCT (10 μm) 9.75 ± 1.71 12.14 ± 2.44 0.57 (0.41 - 0.79) 0.001
   Lipid arc (90°) 1.98 ± 0.39 1.39 ± 0.47 18.08 (4.50 - 72.60) <0.001
   LPL (mm) 6.34 ± 2.04 3.58 ± 2.14 1.80 (1.34 - 2.40) <0.001
   LVI (per 1000) 11.05 ± 3.39 4.81 ± 3.66 1.53 (1.26 - 1.86) <0.001
Macrophages (n, %) 35 (81.4) 23 (33.3) 8.75 (3.50 - 21.89) <0.001
MC (n %) 25 (58.1) 26 (37.7) 2.30 (1.06 - 5.00) 0.036
  1. The data are presented as mean ± SD or n (%) as well as the odds ratio for the vulnerable plaque with the 95% confidence interval (95% CI).
  2. Abbreviations: ACS acute coronary syndrome, SAP stable angina pectoris, BMI body mass index, MAP mean arterial pressure, Fast. Fasting, LDL low density lipoprotein, HDL high density lipoprotein, CRP C-reactive protein, OCT optical coherence tomography, MLA minimal lumen area, MLD minimal lumen diameter, Ref. LA reference luminal area, Pl. plaque, TCFA thin-capped fibroatheroma, FCT fibrous cap thickness, LPL lipid plaque length, LVI lipid volume index, MC microchannel.
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