|
Parameter
|
ACS (n = 43)
|
SAP (n = 69)
|
OR
|
95% CI
|
p-value
|
|---|
|
Clinical:
|
|
Age (years)
|
68.1 ± 9.9
|
69.6 ± 7.4
|
0.98
|
(0.94 - 1.02)
|
ns
|
|
Male (n, %)
|
28 (65.1)
|
47 (68.1)
|
0.87
|
(0.39 - 1.96)
|
ns
|
|
BMI (kg/m2)
|
29.7 ± 5.8
|
31.5 ± 4.8
|
0.93
|
(0.86 - 1.01)
|
0.081
|
|
Hypertension (n, %)
|
35 (81.4)
|
60 (87.0)
|
0.67
|
(0.23 - 1.86)
|
ns
|
|
MAP (mmHg)
|
93.7 ± 11.5
|
96.3 ± 13.0
|
0.98
|
(0.95 - 1.01)
|
ns
|
|
Dyslipidemia (n, %)
|
26 (60.5)
|
47 (68.1)
|
0.72
|
(0.32 - 1.58)
|
ns
|
|
Smoking (n, %)
|
13 (30.2)
|
11 (15.9)
|
2.29
|
(0.91 - 5.71)
|
0.077
|
|
Family history (n, %)
|
14 (32.6)
|
31 (44.9)
|
0.59
|
(0.27 - 1.31)
|
ns
|
|
Diabetes (years)
|
12.3 ± 10.5
|
11.0 ± 9.8
|
1.01
|
(0.98 - 1.05)
|
ns
|
|
HbA1C (%)
|
7.78 ± 1.73
|
7.19 ± 1.45
|
1.27
|
(0.98 - 1.65)
|
0.074
|
|
Fasting glukose (mg/dl)
|
174.8 ± 70.6
|
164.4 ± 46.7
|
1.00
|
(1.00 - 1.01)
|
ns
|
|
Total chol (mg/dl)
|
191.1 ± 43.0
|
189.8 ± 43.8
|
1.00
|
(0.99 - 1.01)
|
ns
|
|
LDL-chol (mg/dl)
|
116.7 ± 36.1
|
117.0 ± 35.7
|
1.00
|
(0.99 - 1.01)
|
ns
|
|
HDL-chol (mg/dl)
|
43.9 ± 14.1
|
43.9 ± 10.5
|
1.00
|
(0.97 - 1.03)
|
ns
|
|
Triglyceride (mg/dl)
|
166.1 ± 92.3
|
187.1 ± 103.6
|
1.00
|
(0.99 - 1.00)
|
ns
|
|
CRP (mg/dl)
|
20.4 ± 30.3
|
9.1 ± 10.7
|
1.03
|
(1.01 - 1.06)
|
0.016
|
|
OCT-derived parameters
|
|
MLA (mm2)
|
1.39 ± 0.76
|
1.42 ± 0.66
|
0.94
|
(0.54 - 1.63)
|
ns
|
|
MLD (mm)
|
1.06 ± 0.26
|
1.13 ± 0.25
|
0.30
|
(0.06 - 1.58)
|
ns
|
|
Ref LA (mm2)
|
6.81 ± 2.36
|
6.51 ± 2.07
|
1.06
|
(0.89 - 1.27)
|
ns
|
|
Stenosis length (mm)
|
9.13 ± 4.22
|
7.98 ± 5.39
|
1.05
|
(0.97 - 1.13)
|
ns
|
|
Area stenosis (%)
|
79.49 ± 7.14
|
77.34 ± 8.62
|
1.03
|
(0.99 - 1.09)
|
ns
|
|
Calcified Pl. (n, %)
|
26 (60.5)
|
48 (69.6)
|
0.67
|
(0.30 - 1.49)
|
ns
|
|
Fibrous Pl. (n, %)
|
33 (76.7)
|
62 (89.9)
|
0.37
|
(0.13 - 1.07)
|
0.066
|
|
Lipid-rich Pl. (n, %)
|
36 (83.7)
|
29 (42.0)
|
7.09
|
(2.77 - 18.16)
|
<0.001
|
|
TCFA n (%)
|
32 (88.9)
|
10 (34.5)
|
15.20
|
(4.18 - 55.28)
|
<0.001
|
|
Non-TCFA (n, %)
|
3 (8.3)
|
19 (65.5)
|
0.05
|
(0.01 - 0.20)
|
<0.001
|
|
Min FCT (10 μm)
|
5.25 ± 0.94
|
8.00 ± 2.44
|
0.39
|
(0.24 - 0.64)
|
<0.001
|
|
Mean FCT (10 μm)
|
9.75 ± 1.71
|
12.14 ± 2.44
|
0.57
|
(0.41 - 0.79)
|
0.001
|
|
Lipid arc (90°)
|
1.98 ± 0.39
|
1.39 ± 0.47
|
18.08
|
(4.50 - 72.60)
|
<0.001
|
|
LPL (mm)
|
6.34 ± 2.04
|
3.58 ± 2.14
|
1.80
|
(1.34 - 2.40)
|
<0.001
|
|
LVI (per 1000)
|
11.05 ± 3.39
|
4.81 ± 3.66
|
1.53
|
(1.26 - 1.86)
|
<0.001
|
|
Macrophages (n, %)
|
35 (81.4)
|
23 (33.3)
|
8.75
|
(3.50 - 21.89)
|
<0.001
|
|
MC (n %)
|
25 (58.1)
|
26 (37.7)
|
2.30
|
(1.06 - 5.00)
|
0.036
|
- The data are presented as mean ± SD or n (%) as well as the odds ratio for the vulnerable plaque with the 95% confidence interval (95% CI).
- Abbreviations: ACS acute coronary syndrome, SAP stable angina pectoris, BMI body mass index, MAP mean arterial pressure, Fast. Fasting, LDL low density lipoprotein, HDL high density lipoprotein, CRP C-reactive protein, OCT optical coherence tomography, MLA minimal lumen area, MLD minimal lumen diameter, Ref. LA reference luminal area, Pl. plaque, TCFA thin-capped fibroatheroma, FCT fibrous cap thickness, LPL lipid plaque length, LVI lipid volume index, MC microchannel.
