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Table 1 Univariable logistic regression analysis for the lesion to be the cause of an ACS

From: A score to quantify coronary plaque vulnerability in high-risk patients with type 2 diabetes: an optical coherence tomography study

Parameter

ACS (n = 43)

SAP (n = 69)

OR

95% CI

p-value

Clinical:

Age (years)

68.1 ± 9.9

69.6 ± 7.4

0.98

(0.94 - 1.02)

ns

Male (n, %)

28 (65.1)

47 (68.1)

0.87

(0.39 - 1.96)

ns

BMI (kg/m2)

29.7 ± 5.8

31.5 ± 4.8

0.93

(0.86 - 1.01)

0.081

Hypertension (n, %)

35 (81.4)

60 (87.0)

0.67

(0.23 - 1.86)

ns

MAP (mmHg)

93.7 ± 11.5

96.3 ± 13.0

0.98

(0.95 - 1.01)

ns

Dyslipidemia (n, %)

26 (60.5)

47 (68.1)

0.72

(0.32 - 1.58)

ns

Smoking (n, %)

13 (30.2)

11 (15.9)

2.29

(0.91 - 5.71)

0.077

Family history (n, %)

14 (32.6)

31 (44.9)

0.59

(0.27 - 1.31)

ns

Diabetes (years)

12.3 ± 10.5

11.0 ± 9.8

1.01

(0.98 - 1.05)

ns

HbA1C (%)

7.78 ± 1.73

7.19 ± 1.45

1.27

(0.98 - 1.65)

0.074

Fasting glukose (mg/dl)

174.8 ± 70.6

164.4 ± 46.7

1.00

(1.00 - 1.01)

ns

Total chol (mg/dl)

191.1 ± 43.0

189.8 ± 43.8

1.00

(0.99 - 1.01)

ns

LDL-chol (mg/dl)

116.7 ± 36.1

117.0 ± 35.7

1.00

(0.99 - 1.01)

ns

HDL-chol (mg/dl)

43.9 ± 14.1

43.9 ± 10.5

1.00

(0.97 - 1.03)

ns

Triglyceride (mg/dl)

166.1 ± 92.3

187.1 ± 103.6

1.00

(0.99 - 1.00)

ns

CRP (mg/dl)

20.4 ± 30.3

9.1 ± 10.7

1.03

(1.01 - 1.06)

0.016

OCT-derived parameters

MLA (mm2)

1.39 ± 0.76

1.42 ± 0.66

0.94

(0.54 - 1.63)

ns

MLD (mm)

1.06 ± 0.26

1.13 ± 0.25

0.30

(0.06 - 1.58)

ns

Ref LA (mm2)

6.81 ± 2.36

6.51 ± 2.07

1.06

(0.89 - 1.27)

ns

Stenosis length (mm)

9.13 ± 4.22

7.98 ± 5.39

1.05

(0.97 - 1.13)

ns

Area stenosis (%)

79.49 ± 7.14

77.34 ± 8.62

1.03

(0.99 - 1.09)

ns

Calcified Pl. (n, %)

26 (60.5)

48 (69.6)

0.67

(0.30 - 1.49)

ns

Fibrous Pl. (n, %)

33 (76.7)

62 (89.9)

0.37

(0.13 - 1.07)

0.066

Lipid-rich Pl. (n, %)

36 (83.7)

29 (42.0)

7.09

(2.77 - 18.16)

<0.001

   TCFA n (%)

32 (88.9)

10 (34.5)

15.20

(4.18 - 55.28)

<0.001

   Non-TCFA (n, %)

3 (8.3)

19 (65.5)

0.05

(0.01 - 0.20)

<0.001

   Min FCT (10 μm)

5.25 ± 0.94

8.00 ± 2.44

0.39

(0.24 - 0.64)

<0.001

   Mean FCT (10 μm)

9.75 ± 1.71

12.14 ± 2.44

0.57

(0.41 - 0.79)

0.001

   Lipid arc (90°)

1.98 ± 0.39

1.39 ± 0.47

18.08

(4.50 - 72.60)

<0.001

   LPL (mm)

6.34 ± 2.04

3.58 ± 2.14

1.80

(1.34 - 2.40)

<0.001

   LVI (per 1000)

11.05 ± 3.39

4.81 ± 3.66

1.53

(1.26 - 1.86)

<0.001

Macrophages (n, %)

35 (81.4)

23 (33.3)

8.75

(3.50 - 21.89)

<0.001

MC (n %)

25 (58.1)

26 (37.7)

2.30

(1.06 - 5.00)

0.036

  1. The data are presented as mean ± SD or n (%) as well as the odds ratio for the vulnerable plaque with the 95% confidence interval (95% CI).
  2. Abbreviations: ACS acute coronary syndrome, SAP stable angina pectoris, BMI body mass index, MAP mean arterial pressure, Fast. Fasting, LDL low density lipoprotein, HDL high density lipoprotein, CRP C-reactive protein, OCT optical coherence tomography, MLA minimal lumen area, MLD minimal lumen diameter, Ref. LA reference luminal area, Pl. plaque, TCFA thin-capped fibroatheroma, FCT fibrous cap thickness, LPL lipid plaque length, LVI lipid volume index, MC microchannel.