Table 2 Aging and GLP-1 on left ventricular and systemic hemodynamics after 3 weeks of GLP-1 treatment and before the onset of DCM

LVESP ( mmHg)

118 ± 4

132 ± 10

NS

130 ± 10

NS

LVEDP (mmHg)

9 ± 1

11 ± 2

NS

10 ± 3

NS

LV dP/dt ( mmHg /sec)

2881 ± 121

2801 ± 176

NS

2912 ± 200

NS

LV tau (msec)

18 ± 1

25 ± 2

<0.01

19 ± 1†

NS

MAP ( mmHg)

89 ± 3

107 ± 7

<0.05

102 ± 5

<0.05

Heart Rate (min-1 )

90 ± 4

101 ± 10

NS

99 ± 12

NS

CO (L/min)

2.7 ± 0.3

2.5 ± 0.3

NS

2.5 ± 0.4

NS

LVEF (%)

54 ± 4

50 ± 5

NS

51 ± 4

NS

SVR (dyne-sec-cm-5)

2649 ± 267

3421 ± 224

<0.05

3164 ± 123

NS

MVO₂ (ml O₂/min)

150 ± 21

313 ± 39

<0.01

243 ± 22†

<0.01

Coronary Flow (ml/min)

25 ± 3

26 ± 4

NS

27 ± 4

NS

LVEDD (mm)

40 ± 3

40 ± 3

NS

41 ± 3

NS

LVESD (mm)

33 ± 2

34 ± 3

NS

33 ± 3

NS