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Figure 5 | Cardiovascular Diabetology

Figure 5

From: GLP-1 (7–36) amide restores myocardial insulin sensitivity and prevents the progression of heart failure in senescent beagles

Figure 5

Effects of age and GLP-1 infusion on reactive oxygen species and mitochondrial protein expression. Aging was associated with higher levels of malondialdehyde (A) and decreased mitochondrial expression of UCP-3 and MCO (B) compared to Young-Control. GLP-1 treatment decreased malondialdehyde abundance (A) and increased mitochondrial protein expression (B) in Old + GLP-1 compared to Old-Control. MCO, mitochondrial cytochrome oxidase-1; UCP-3, uncoupling protein-3. *Old-Control versus Old + GLP-1, p < 0.05; #Old-Control versus Young-Control #p < 0.01.

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Cardiovascular Diabetology

ISSN: 1475-2840