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Figure 3 | Cardiovascular Diabetology

Figure 3

From: p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity

Figure 3

eNOS-uncoupling in obesity. Confocal microscopic en face detection of NO and O2- by DAF-2DA and DHE staining, respectively, followed by counterstaining with DAPI of aortas. Aortas of WT mice fed NC or HFD were treated with or without the eNOS inhibitor L-NAME (1 mmol/L) for 1 hour followed by acetylcholine (ACh) stimulation (1 μmol/L, 10 minutes) and then DAF-2DA and DHE staining. n = 5; ***p < 0.005 vs NC; †††p < 0.005 vs HFD group. Scale bar = 0.1 mm.

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