Figure 2
From: p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity
Arg-II gene deficiency prevents HFD-induced impairment of endothelium-dependent relaxation. (A) Endothelium-dependent relaxations in response to acetylcholine (ACh) were significantly impaired by HFD feeding in WT mice () and preserved in Arg-II-/- mice (). Arg-II deficiency had no significant effects in mice fed NC. (B) Arg-II deficiency does not affect endothelium-independent relaxations in response to the NO donor sodium nitroprusside (SNP) in animals fed HFD. n = 6, **p < 0.01 between WT HFD and Arg-II-/- HFD groups.