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Table 2 Laboratory characteristics of the study group in relation to platelet reactivity, expressed as quartiles of serum thromboxane B 2 concentration

From: Younger age, higher body mass index and lower adiponectin concentration predict higher serum thromboxane B2 level in aspirin-treated patients with type 2 diabetes: an observational study

Laboratory parameters

TXB2

TXB2

TXB2

TXB2

p

<50 pg/mL

[50-150 pg/mL)

[150-450 pg/mL)

≥450 pg/mL

n = 45

n = 49

n = 47

n = 45

Insulin resistance parameters and adipokines

HOMA-IR

3.23 (2.29-4.94)

3.54 (2.42-6.07)

4.48 (2.62-7.29)

4.25 (3.16-8.12)

0.019

Insulin [μIU/mL]

11.22 (7.66-15.50)

11.54 (8.88-20.17)

14.24 (9.30-21.00)

15.44 (10.01-21.09)

0.076

C-peptide [ng/mL]

3.756 (2.964-4.680)

3.852 (3.096-5.556)

3.948 (3.360-5.316)

4.260 (3.552-4.908)

0.095

HMW adiponectin [μg/mL]

3.86 (2.28-5.20)

3.15 (2.20-5.54)

2.31 (1.55-3.24)

2.41 (1.65-3.40)

0.002

Leptin [ng/mL]

14.52 (9.40-22.16)

18.40 (9.02-26.09)

15.54 (9.68-33.02)

19.21 (8.24-37.10)

0.36

Resistin [ng/mL]

6.85 (5.21-9.73)

7.50 (5.91-8.60)

6.55 (5.58-7.97)

6.66 (4.91-8.69)

0.41

Glycemic control parameters

HbA1c [%]

6.2 (6.1-6.6)

6.5 (6.0-7.1)

6.5 (5.9-7.2)

6.6 (6.3-7.6)

0.018

HbA1c target achieved

38 (84.4%)

33 (67.4%)

32 (68.1%)

29 (64.4%)

0.051

Fasting glycemia [mg/dL]

116 (102-130)

120 (107-136)

120 (104-147)

126 (108-155)

0.041

Lipid control parameters

TC [mg/dL]

159.3 (±46.8)

165.3 (±36.6)

178.1 (±34.0)

164.7 (±34.0)

0.12

LDL cholesterol [mg/dL]

83.3 (±28.4)

87.5 (±31.3)

96.4 (±30.9)

88.9 (±29.4)

0.23

LDL cholesterol target achieved

22 (48.9%)

22 (44.9%)

16 (34.0%)

22 (48.9%)

0.73

HDL cholesterol [mg/dL]

47.8 (±10.1)

51.7 (±17.8)

49.4 (±12.5)

46.4 (±11.2)

0.58

HDL cholesterol target achieved

25 (55.6%)

22 (44.9%)

18 (38.3%)

22 (48.9%)

0.42

TG [mg/dL]

122.0 (±46.0)

125.6 (±59.5)

158.0 (±77.7)

153.2 (±71.5)

0.010

TG target achieved

35 (77.8%)

38 (77.6%)

27 (57.5%)

27 (60.0%)

0.016

Other laboratory parameters

PLT [103/μL]

214.5 (±64.7)

229.5 (±59.0)

241.4 (±67.1)

224.8 (±44.8)

0.30

MPV [fL]

10.0 (±1.3)

9.9 (±1.2)

9.5 (±1.1)

10.0 (±1.2)

0.65

WBC [103/μL]

6.46 (±1.31)

6.75 (±1.83)

7.26 (±1.53)

6.83 (±1.95)

0.24

RBC [106/μL]

4.73 (±0.43)

4.58 (±0.54)

4.67 (±0.46)

4.66 (±0.40)

0.83

Hemoglobin [g/dL]

14.0 (±1.2)

13.8 (±1.3)

14.1 (±1.2)

14.0 (±1.2)

0.77

Hematocrit [%]

42.2 (±3.5)

41.2 (±3.8)

42.2 (±3.5)

41.6 (±3.3)

0.99

Fibrinogen [mg/dL]

417.2 (±101.3)

443.8 (±106.7)

440.8 (±126.2)

408.3 (±95.5)

0.59

vWF activity (%)

138.3 (96.8-157.9)

141.0 (112.7-185.1)

134.3 (102.3-199.1)

111.8 (89.6-165.1)

0.49

APTT [s]

29.3 (±3.7)

29.2 (±3.2)

28.9 (±4.7)

29.2 (±4.0)

0.82

INR

0.97 (0.93-1.03)

0.96 (0.91-1.00)

0.95 (0.92-0.98)

0.98 (0.92-1.02)

0.79

hsCRP [mg/dL]

1.6 (1.1-3.3)

2.9 (1.5-4.9)

3.2 (2.2-5.7)

2.7 (1.4-4.4)

0.023

eGFR [mL/min/1,73m2]

74.3 (62.1-90.3)

68.4 (59.3-87.7)

78.1 (67.0-93.2)

77.1 (63.7-91.2)

0.24

Urea [mg/dL]

41.0 (±11.2)

43.3 (±12.7)

37.6 (±11.4)

39.0 (±10.0)

0.092

UA [mg/dL]

5.9 (±1.4)

5.6 (±1.6)

5.6 (±1.4)

5.8 (±1.4)

0.91

  1. Relative frequency, standard deviations and interquartile ranges (IQR) are presented in parentheses.
  2. TXB2 - thromboxane B2; HOMA-IR - Homeostasis Model Assessment-Insulin Resistance; HMW - high-molecular weight; HbA1c - glycated hemoglobin; TG - triglycerides; HDL - high-density lipoprotein; TC - total cholesterol; LDL - low-density lipoprotein; PLT - platelet count; MPV - mean platelet volume; WBC - white blood cell count; RBC - red blood cell count; vWF - von Willebrand factor; APTT - activated partial thromboplastin time; INR - international normalized ratio; hsCRP - high-sensitivity C-reactive protein; eGFR - estimated glomerular filtration rate; UA - uric acid. Bold font indicates p-values ≤0.05.
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Cardiovascular Diabetology

ISSN: 1475-2840