| Baseline | 4 weeks | 12 weeks | PTV# | ATV# | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
 | PTV | ATV | P-value | PTV | ATV | P-value | PTV | ATV | P-value | P-value | P-value |
WBC (/cumm) | 6223 ± 1790 | 7184 ± 1563 | 0.16 | 6784 ± 2106 | 7238 ± 1180 | 0.50 | 6338 ± 1809 | 6930 ± 1245 | 0.34 | 0.73 | 0.82 |
Glucose (mmol/L) | 6.98 ± 1.39 | 6.28 ± 1.04 | 0.16 | 7.12 ± 1.71 | 6.54 ± 1.23 | 0.39 | 7.58 ± 2.54 | 6.54 ± 1.05 | 0.18 | 0.71 | 0.80 |
HOMA-IR | 1.9 ± 1.2 | 2.0 ± 1.0 | 0.78 |  |  |  | 5.2 ± 4.8 | 3.9 ± 2.8 | 0.41 | 0.05 | <0.05 |
hs-CRP (mg/dL) | 0.18 ± 0.18 | 0.35 ± 0.37 | 0.16 | 0.17 ± 0.11 | 0.16 ± 0.19 | 0.90 | 0.20 ± 0.20 | 0.17 ± 0.20 | 0.88 | 0.93 | 0.17 |
TC (mmol/L) | 5.20 ± 0.69 | 5.24 ± 0.64 | 0.89 | 3.73 ± 0.53 | 3.62 ± 0.36 | 0.53 | 3.65 ± 0.52 | 3.56 ± 0.37 | 0.58 | <0.05 | <0.05 |
TG (mmol/L) | 1.53 ± 0.71 | 1.72 ± 0.59 | 0.46 | 1.25 ± 0.58 | 1.26 ± 0.28 | 0.94 | 1.15 ± 0.51 | 1.22 ± 0.39 | 0.72 | 0.26 | <0.05 |
LDL-c (mmol/L) | 3.70 ± 0.55 | 3.82 ± 0.85 | 0.68 | 2.12 ± 0.46 | 2.19 ± 0.45 | 0.68 | 2.14 ± 0.33 | 2.09 ± 0.51 | 0.76 | <0.05 | <0.05 |
HDL-c (mmol/L) | 1.25 ± 0.25 | 1.18 ± 0.19 | 0.38 | 1.29 ± 0.33 | 1.18 ± 0.18 | 0.32 | 1.25 ± 0.28 | 1.19 ± 0.20 | 0.58 | 0.92 | 0.96 |
NOx (μmol/L) | 70.8 ± 42.5 | 78.5 ± 96.8 | 0.80 | 75.3 ± 66.1 | 80.6 ± 62.9 | 0.85 | 79.5 ± 86.1 | 68.9 ± 46.4 | 0.71 | 0.95 | 0.91 |
IL-10 (pg/ml) | 1.8 ± 1.2 | 1.5 ± 0.8 | 0.48 | 2.1 ± 1.6 | 2.1 ± 1.4 | 0.91 | 2.07 ± 1.6 | 1.7 ± 1.8 | 0.57 | 0.87 | 0.55 |
TNF-α (pg/ml) | 3.6 ± 1.7 | 4.0 ± 2.8 | 0.67 | 3.3 ± 1.8 | 4.5 ± 2.8 | 0.22 | 2.8 ± 0.8 | 4.3 ± 3.2 | 0.12 | 0.45 | 0.91 |
ADMA (μmol/L) | 0.61 ± 0.10 | 0.68 ± 0.10 | 0.09 |  |  |  | 0.56 ± 0.12 | 0.53 ± 0.12 | 0.55 | 0.25 | <0.05 |
SDF-1α (pg/ml) | 2619.9 ± 640.5 | 2851.4 ± 669.1 | 0.38 | 2673.5 ± 774.6 | 3043.3 ± 733.5 | 0.24 | 2603.6 ± 757.1 | 3085.5 ± 701.1 | 0.16 | 0.98 | 0.668 |
VEGF (pg/ml) | 74.33 ± 32.26 | 69.86 ± 31.53 | 0.72 | 118.36 ± 50.05 | 67.65 ± 42.85 | 0.01 | 98.65 ± 46.64 | 74.04 ± 29.33 | 0.12 | <0.05 | 0.898 |
EPC level (%) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
CD34+KDR+ | 0.021 ± 0.015 | 0.039 ± 0.039 | 0.16 | 0.035 ± 0.031 | 0.029 ± 0.024 | 0.59 | 0.054 ± 0.044 | 0.043 ± 0.029 | 0.45 | <0.05 | 0.57 |