Figure 1

Study protocol. The patients were followed for at least 8 weeks to confirm that they did not achieve the treatment goal. The patients were prospectively, randomly assigned to additional treatment with either sitagliptin (50 mg/day) or voglibose (0.6 mg/day) for 12 weeks. Measurements of flow-mediated dilatation (FMD) of the brachial artery and blood and urine tests were performed in the fasting state at baseline and after 12 weeks of treatment.