High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury

Table 3 Effects of diets and preconditioning on myocardial function before and after ischaema

	CF	AO	CO	HR	PSP	TW	Number of hearts producing AO during reperfusion
	(ml/min)	(ml/min)	(ml/min)	(beats/min)	(mmHg)	(mmHg)	Number of hearts producing AO during reperfusion
Before ischaemia (45)	20.5 ± 0.5	37.6 ± 1.0	58.2 ± 1.1	257 ± 4	92 ± 1	11.6 ± 0.39
After ischaemia
NDC NPC	9.1 ± 4.1*	4.8 ± 2.9***	13.9 ± 6.8*	167 ± 68	49 ± 20	3.09 ± 1.31*	2/5
IPC	15.2 ± 0.8	23.2 ± 2.3*^†	38.4 ± 3.0*^†	301 ± 34	83 ± 2	7.49 ± 0.86^†	5/5
BPC	16.3 ± 1.0	16.8 ± 4.7**^†	33.5 ± 6.0*	252 ± 18	85 ± 3	6.58 ± 1.35	5/5
DI0 NPC	6.4 ± 4.1**	4.0 ± 2.5***	10.4 ± 6.6*	96 ± 59	32 ± 20*	1.88 ± 1.21***	3/5
IPC	15.2 ± 4.1	20.0 ± 5.2**^†	35.2 ± 1.1*^†	211 ± 53	71 ± 18	7.07 ± 1.78^†	4/5
BPC	15.8 ± 1.2	15.2 ± 2.3**^†	31 ± 3.3*^†	278 ± 13	85 ± 2	5.75 ± 0.81^†	5/5
HFD NPC	8.8 ± 3.7*	4.8 ± 2.3***	14.4 ± 6.0**	141 ± 58	49 ± 20	2.66 ± 1.09***	2/5
IPC	13.6 ± 3.5	13.2 ± 5.2***	26.8 ± 7.8*	210 ± 55	69 ± 17	5.18 ± 1.50*	4/5
BPC	8.7 ± 3.9*	9.0 ± 5.4***	17.0 ± 8.4**	126 ± 57*	42 ± 19	3.36 ± 1.64**	3/6

Abbreviations: CF Coronary flow, AO Aortic output, CO Cardiac output, HR heart rate, PSP peak systolic pressure, TW total work.
NPC non-preconditioned, IPC ischaemic preconditioning, BPC beta-preconditioning.
Five-six hearts were studied in each series. Values obtained before ischaemia were grouped together.
*p < 0.05 vs Before; **p < 0.01 vs Before; ***p < 0.001 vs Before; ^†p < 0.05 vs NPC.

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