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Table 3 The adjusted odds ratios for metabolic syndrome, its components, and insulin resistance in relation to tertiles of hsCRP and GGT

From: High-sensitivity c-reactive protein and gamma-glutamyl transferase levels are synergistically associated with metabolic syndrome in community-dwelling persons

  Men, N = 822 Women, N = 1,097
  Tertile of hsCRP Tertile of GGT Tertile of hsCRP Tertile of GGT
  1st 2nd 3rd 1st 2nd 3rd 1st 2nd 3rd 1st 2nd 3rd
Characteristics <0.360 0.360-0.800 >0.800 mg/L <29 29-54 >54 IU/L <0.280 0.280-0.650 >0.650 mg/L <18 18-24 >24 IU/L
Metabolic syndrome 29 (20.6%) 49 (34.8%) 63 (44.7%) 19 (13.5%) 51 (36.2%) 71 (50.4%) 25 (14.7%) 47 (27.6%) 98 (57.6%) 29 (17.1%) 54 (31.8%) 87 (51.2%)
   OR (95% CI) 1.00 1.69 (1.01-2.80) 2.13 (1.29-3.52) 1.00 3.26 (1.84-5.78) 6.11 (3.30-11.3) 1.00 1.54 (0.92-2.60) 3.08 (1.88-5.06) 1.00 1.70 (1.04-2.79) 2.67 (1.66-4.30)
Obesity 61 (24.9%) 72 (29.4%) 112 (45.7%) 40 (16.3%) 88 (35.9%) 117 (47.8%) 49 (15.1%) 103 (31.7%) 173 (53.2%) 66 (20.3%) 107 (32.9%) 152 (46.8%)
   OR (95% CI) 1.00 1.16 (0.76-1.76) 2.21 (1.47-3.32) 1.00 2.65 (1.71-4.12) 4.75 (2.92-7.72) 1.00 2.15 (1.46-3.18) 4.04 (2.74-5.97) 1.00 1.60 (1.11-2.32) 2.17 (1.50-3.12)
Raised blood pressure 186 (31.2%) 201 (33.7%) 209 (35.1%) 184 (30.9%) 208 (34.9%) 204 (34.2%) 220 (30.0%) 249 (34.0%) 264 (36.0%) 236 (32.2%) 245 (33.4%) 252 (34.4%)
   OR (95% CI) 1.00 1.34 (0.88-2.03) 1.20 (0.78-1.85) 1.00 2.13 (1.38-3.29) 2.72 (1.67-4.43) 1.00 1.02 (0.71-1.46) 0.97 (0.66-1.42) 1.00 1.22 (0.85-1.74) 1.19 (0.82-1.73)
Hypertriglyceridemia 49 (27.7%) 62 (35.0%) 66 (37.3%) 28 (15.8%) 51 (28.8%) 98 (55.4%) 31 (19.4%) 49 (30.6%) 80 (50.0%) 26 (16.3%) 40 (25.0%) 94 (58.8%)
   OR (95% CI) 1.00 1.21 (0.77-1.88) 1.21 (0.77-1.88) 1.00 2.03 (1.22-3.37) 5.43 (3.18-9.26) 1.00 1.20 (0.73-1.97) 1.68 (1.03-2.71) 1.00 1.47 (0.87-2.49) 3.92 (2.40-6.38)
Low HDL cholesterolemia 10 (15.9%) 26 (41.3%) 27 (42.9%) 23 (33.8) 24 (38.1%) 16 (25.4%) 42 (23.7%) 55 (31.1%) 80 (45.2%) 53 (29.9%) 59 (33.3%) 65 (36.7%)
   OR (95% CI) 1.00 2.85 (1.33-6.12) 2.79 (1.28-6.07) 1.00 0.94 (0.50-1.76) 0.76 (0.36-1.64) 1.00 1.29 (0.83-2.00) 1.95 (1.25-3.02) 1.00 1.12 (0.74-1.69) 1.17 (0.77-1.79)
Impaired fasting glucose 46 (23.8%) 70 (36.3%) 77 (39.9%) 50 (25.9%) 62 (32.1%) 81 (42.0%) 28 (19.3%) 38 (26.2%) 79 (54.5%) 28 (19.3%) 46 (31.7%) 71 (49.0%)
   OR (95% CI) 1.00 1.73 (1.12-2.67) 1.82 (1.17-2.82) 1.00 1.54 (0.99-2.40) 2.81 (1.72-4.59) 1.00 1.12 (0.66-1.90) 2.24 (1.37-3.66) 1.00 1.55 (0.93-2.59) 2.36 (1.44-3.88)
HOMA-IR ≥2.6† 12 (11.9%) 37 (36.6%) 52 (51.5%) 18 (17.8%) 36 (35.6%) 47 (46.5%) 23 (13.3%) 49 (28.3%) 101 (58.4%) 18 (10.4%) 58 (33.5%) 97 (56.1)
   OR (95% CI) 1.00 3.40 (1.08-3.73) 5.14 (2.60-10.1) 1.00 2.01 (1.08-3.73) 3.00 (1.55-5.82) 1.00 1.78 (1.04-3.04) 3.51 (2.11-5.86) 1.00 3.13 (1.78-5.49) 4.99 (2.89-8.64)
  1. Study subjects were divided into three groups (tertiles) according to hsCRP and GGT levels within sex. OR, odds ratio; CI, confidence interval.
  2. † Insulin resistance was defined as HOMA-IR ≥2.6. Adjusted for age, smoking status, alcohol consumption, uric acid, and estimated glomerular filtration rate.