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Table 3 The adjusted odds ratios for metabolic syndrome, its components, and insulin resistance in relation to tertiles of hsCRP and GGT

From: High-sensitivity c-reactive protein and gamma-glutamyl transferase levels are synergistically associated with metabolic syndrome in community-dwelling persons

 

Men, N = 822

Women, N = 1,097

 

Tertile of hsCRP

Tertile of GGT

Tertile of hsCRP

Tertile of GGT

 

1st

2nd

3rd

1st

2nd

3rd

1st

2nd

3rd

1st

2nd

3rd

Characteristics

<0.360

0.360-0.800

>0.800 mg/L

<29

29-54

>54 IU/L

<0.280

0.280-0.650

>0.650 mg/L

<18

18-24

>24 IU/L

Metabolic syndrome

29 (20.6%)

49 (34.8%)

63 (44.7%)

19 (13.5%)

51 (36.2%)

71 (50.4%)

25 (14.7%)

47 (27.6%)

98 (57.6%)

29 (17.1%)

54 (31.8%)

87 (51.2%)

   OR (95% CI)

1.00

1.69 (1.01-2.80)

2.13 (1.29-3.52)

1.00

3.26 (1.84-5.78)

6.11 (3.30-11.3)

1.00

1.54 (0.92-2.60)

3.08 (1.88-5.06)

1.00

1.70 (1.04-2.79)

2.67 (1.66-4.30)

Obesity

61 (24.9%)

72 (29.4%)

112 (45.7%)

40 (16.3%)

88 (35.9%)

117 (47.8%)

49 (15.1%)

103 (31.7%)

173 (53.2%)

66 (20.3%)

107 (32.9%)

152 (46.8%)

   OR (95% CI)

1.00

1.16 (0.76-1.76)

2.21 (1.47-3.32)

1.00

2.65 (1.71-4.12)

4.75 (2.92-7.72)

1.00

2.15 (1.46-3.18)

4.04 (2.74-5.97)

1.00

1.60 (1.11-2.32)

2.17 (1.50-3.12)

Raised blood pressure

186 (31.2%)

201 (33.7%)

209 (35.1%)

184 (30.9%)

208 (34.9%)

204 (34.2%)

220 (30.0%)

249 (34.0%)

264 (36.0%)

236 (32.2%)

245 (33.4%)

252 (34.4%)

   OR (95% CI)

1.00

1.34 (0.88-2.03)

1.20 (0.78-1.85)

1.00

2.13 (1.38-3.29)

2.72 (1.67-4.43)

1.00

1.02 (0.71-1.46)

0.97 (0.66-1.42)

1.00

1.22 (0.85-1.74)

1.19 (0.82-1.73)

Hypertriglyceridemia

49 (27.7%)

62 (35.0%)

66 (37.3%)

28 (15.8%)

51 (28.8%)

98 (55.4%)

31 (19.4%)

49 (30.6%)

80 (50.0%)

26 (16.3%)

40 (25.0%)

94 (58.8%)

   OR (95% CI)

1.00

1.21 (0.77-1.88)

1.21 (0.77-1.88)

1.00

2.03 (1.22-3.37)

5.43 (3.18-9.26)

1.00

1.20 (0.73-1.97)

1.68 (1.03-2.71)

1.00

1.47 (0.87-2.49)

3.92 (2.40-6.38)

Low HDL cholesterolemia

10 (15.9%)

26 (41.3%)

27 (42.9%)

23 (33.8)

24 (38.1%)

16 (25.4%)

42 (23.7%)

55 (31.1%)

80 (45.2%)

53 (29.9%)

59 (33.3%)

65 (36.7%)

   OR (95% CI)

1.00

2.85 (1.33-6.12)

2.79 (1.28-6.07)

1.00

0.94 (0.50-1.76)

0.76 (0.36-1.64)

1.00

1.29 (0.83-2.00)

1.95 (1.25-3.02)

1.00

1.12 (0.74-1.69)

1.17 (0.77-1.79)

Impaired fasting glucose

46 (23.8%)

70 (36.3%)

77 (39.9%)

50 (25.9%)

62 (32.1%)

81 (42.0%)

28 (19.3%)

38 (26.2%)

79 (54.5%)

28 (19.3%)

46 (31.7%)

71 (49.0%)

   OR (95% CI)

1.00

1.73 (1.12-2.67)

1.82 (1.17-2.82)

1.00

1.54 (0.99-2.40)

2.81 (1.72-4.59)

1.00

1.12 (0.66-1.90)

2.24 (1.37-3.66)

1.00

1.55 (0.93-2.59)

2.36 (1.44-3.88)

HOMA-IR ≥2.6†

12 (11.9%)

37 (36.6%)

52 (51.5%)

18 (17.8%)

36 (35.6%)

47 (46.5%)

23 (13.3%)

49 (28.3%)

101 (58.4%)

18 (10.4%)

58 (33.5%)

97 (56.1)

   OR (95% CI)

1.00

3.40 (1.08-3.73)

5.14 (2.60-10.1)

1.00

2.01 (1.08-3.73)

3.00 (1.55-5.82)

1.00

1.78 (1.04-3.04)

3.51 (2.11-5.86)

1.00

3.13 (1.78-5.49)

4.99 (2.89-8.64)

  1. Study subjects were divided into three groups (tertiles) according to hsCRP and GGT levels within sex. OR, odds ratio; CI, confidence interval.
  2. † Insulin resistance was defined as HOMA-IR ≥2.6. Adjusted for age, smoking status, alcohol consumption, uric acid, and estimated glomerular filtration rate.
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Cardiovascular Diabetology

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