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Table 2 Association between various characteristics, and metabolic syndrome components and Insulin resistance

From: High-sensitivity c-reactive protein and gamma-glutamyl transferase levels are synergistically associated with metabolic syndrome in community-dwelling persons

 

Metabolic syndrome

HOMA-IR

 

Men, N = 822

 

Women, N = 1,097

 

Men, N = 822

Women, N = 1,097

       

Pearson's correlation

Characteristics

No

N = 681

Yes

N = 141

P-value*

No

N = 927

Yes

N = 170

P-value*

r (P-value)

r (P-value)

Age (years)

61 ± 14

60 ± 12

0.342

62 ± 12

66 ± 9

0.001

-0.141 (<0.001)

0.100 (0.001)

Body mass index (kg/m2)

23.1 ± 2.8

26.1 ± 2.6

<0.001

22.8 ± 2.9

26.8 ± 3.6

<0.001

0.547 (<0.001)

0.516 (<0.001)

Smoking status, %

41.4/23.9/15.7/18.9

42.6/29.1/9.2/19.1

0.199

97.4/0.8/1.7/0.1

98.2/1.2/0.6/0

0.636

-0.081 (0.020)

0.019 (0.536)

Alcohol consumption, %

14.4/28.0/35.4/22.2

15.6/30.5/29.1/24.8

0.555

63.3/30.9/5.4/0.4

71.8/25.3/2.4/0.6

0.120

-0.064 (0.066)

-0.049 (0.104)

History of cardiovascular disease, %

23.6

29.8

0.078

6.3

10.0

0.058

0.048 (0.171)

0.051 (0.090)

Systolic blood pressure (mmHg)

139 ± 20

156 ± 17

0.001

136 ± 23

150 ± 20

<0.001

0.137 (<0.001)

0.245 (<0.001)

Diastolic blood pressure (mmHg)

84 ± 11

88 ± 10

<0.001

79 ± 12

86 ± 10

<0.001

0.181 (<0.001)

0.230 (<0.001)

Antihypertensive medication, %

23.6

29.8

0.078

21.1

50.0

<0.001

0.124 (<0.001)

0.195 (<0.001)

Triglycerides (mmol/L)

1.00 (0.77-1.33)

1.89 (1.52-2.60)

<0.001

0.94 (0.72-1.23)

1.76 (1.21-2.12)

<0.001

0.392 (<0.001)

0.365 (<0.001)

HDL cholesterol (mmol/L)

1.58 ± 0.37

1.27 ± 0.36

<0.001

1.74 ± 0.38

1.32 ± 0.32

<0.001

-0.319 (<0.001)

-0.232 (<0.001)

LDL cholesterol (mmol/L)

2.83 ± 0.79

3.01 ± 0.92

0.019

3.24 ± 0.74

3.40 ± 0.85

0.011

0.206 (<0.001)

0.200 (<0.001)

Antilipidemic medication, %

3.7

5.0

0.301

5.7

11.8

0.005

0.070 (0.044)

0.088 (0.004)

Serum uric acid (μmol/L)

349 ± 81

360 ± 91

0.146

261 ± 61

291 ± 58

<0.001

0.171 (<0.001)

0.252 (<0.001)

eGFR (mL/min/1.73 m2)

80.9 ± 16.7

82.3 ± 18.6

0.385

80.9 ± 17.1

76.3 ± 16.2

0.001

-0.009 (0.791)

-0.068 (0.024)

Fasting blood glucose (mmol/L)

5.22 (4.94-5.61)

6.11 (5.27-6.83)

<0.001

5.05 (4.83-5.44)

5.61 (5.11-6.61)

<0.001

0.474 (<0.001)

0.540 (<0.001)

HOMA-IR

1.01 (0.65-1.64)

2.21 (1.43-3.20)

<0.001

1.27 (0.85-1.79)

2.52 (1.80-3.79)

<0.001

----------

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Diabetic medication, %

2.8

9.9

<0.001

2.2

8.8

<0.001

0.112 (0.001)

0.133 (<0.001)

HMW adiponectin (μg/mL)

3.63 (2.18-5.65)

2.28 (1.60-3.69)

<0.001

7.09 (4.69-10.3)

4.48 (3.12-7.17)

<0.001

-0.331 (<0.001)

-0.340 (<0.001)

hsCRP (mg/L)

0.480 (0.275-1.015)

0.690 (0.400-1.535)

<0.001

0.380 (0.200-0.760)

0.750 (0.390-1.613)

<0.001

0.163 (<0.001)

0.290 (<0.001)

GGT (IU/L)

35 (24-61)

55 (36-102)

<0.001

20 (15-26)

25 (19-35)

<0.001

0.240 (<0.001)

0.328 (<0.001)

  1. Data presented are mean ± standard deviation. Metabolic syndrome was defined as having three or more of the following conditions: obesity, raised blood pressure, hypertriglyceridemia, low HDL- cholesterolemia, and impaired fasting blood glucose. Data for triglycerides, fasting blood glucose, HOMA-IR, HMW adiponectin, hsCRP, and GGT were skewed and are presented as median (interquartile range) values, and were log-transformed for analysis. *P-value from Student's t-test for continuous variables or from χ2-test for categorical variables.