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Table 2 Association between various characteristics, and metabolic syndrome components and Insulin resistance

From: High-sensitivity c-reactive protein and gamma-glutamyl transferase levels are synergistically associated with metabolic syndrome in community-dwelling persons

  Metabolic syndrome HOMA-IR
  Men, N = 822   Women, N = 1,097   Men, N = 822 Women, N = 1,097
        Pearson's correlation
Characteristics No
N = 681
Yes
N = 141
P-value* No
N = 927
Yes
N = 170
P-value* r (P-value) r (P-value)
Age (years) 61 ± 14 60 ± 12 0.342 62 ± 12 66 ± 9 0.001 -0.141 (<0.001) 0.100 (0.001)
Body mass index (kg/m2) 23.1 ± 2.8 26.1 ± 2.6 <0.001 22.8 ± 2.9 26.8 ± 3.6 <0.001 0.547 (<0.001) 0.516 (<0.001)
Smoking status, % 41.4/23.9/15.7/18.9 42.6/29.1/9.2/19.1 0.199 97.4/0.8/1.7/0.1 98.2/1.2/0.6/0 0.636 -0.081 (0.020) 0.019 (0.536)
Alcohol consumption, % 14.4/28.0/35.4/22.2 15.6/30.5/29.1/24.8 0.555 63.3/30.9/5.4/0.4 71.8/25.3/2.4/0.6 0.120 -0.064 (0.066) -0.049 (0.104)
History of cardiovascular disease, % 23.6 29.8 0.078 6.3 10.0 0.058 0.048 (0.171) 0.051 (0.090)
Systolic blood pressure (mmHg) 139 ± 20 156 ± 17 0.001 136 ± 23 150 ± 20 <0.001 0.137 (<0.001) 0.245 (<0.001)
Diastolic blood pressure (mmHg) 84 ± 11 88 ± 10 <0.001 79 ± 12 86 ± 10 <0.001 0.181 (<0.001) 0.230 (<0.001)
Antihypertensive medication, % 23.6 29.8 0.078 21.1 50.0 <0.001 0.124 (<0.001) 0.195 (<0.001)
Triglycerides (mmol/L) 1.00 (0.77-1.33) 1.89 (1.52-2.60) <0.001 0.94 (0.72-1.23) 1.76 (1.21-2.12) <0.001 0.392 (<0.001) 0.365 (<0.001)
HDL cholesterol (mmol/L) 1.58 ± 0.37 1.27 ± 0.36 <0.001 1.74 ± 0.38 1.32 ± 0.32 <0.001 -0.319 (<0.001) -0.232 (<0.001)
LDL cholesterol (mmol/L) 2.83 ± 0.79 3.01 ± 0.92 0.019 3.24 ± 0.74 3.40 ± 0.85 0.011 0.206 (<0.001) 0.200 (<0.001)
Antilipidemic medication, % 3.7 5.0 0.301 5.7 11.8 0.005 0.070 (0.044) 0.088 (0.004)
Serum uric acid (μmol/L) 349 ± 81 360 ± 91 0.146 261 ± 61 291 ± 58 <0.001 0.171 (<0.001) 0.252 (<0.001)
eGFR (mL/min/1.73 m2) 80.9 ± 16.7 82.3 ± 18.6 0.385 80.9 ± 17.1 76.3 ± 16.2 0.001 -0.009 (0.791) -0.068 (0.024)
Fasting blood glucose (mmol/L) 5.22 (4.94-5.61) 6.11 (5.27-6.83) <0.001 5.05 (4.83-5.44) 5.61 (5.11-6.61) <0.001 0.474 (<0.001) 0.540 (<0.001)
HOMA-IR 1.01 (0.65-1.64) 2.21 (1.43-3.20) <0.001 1.27 (0.85-1.79) 2.52 (1.80-3.79) <0.001 ---------- ----------
Diabetic medication, % 2.8 9.9 <0.001 2.2 8.8 <0.001 0.112 (0.001) 0.133 (<0.001)
HMW adiponectin (μg/mL) 3.63 (2.18-5.65) 2.28 (1.60-3.69) <0.001 7.09 (4.69-10.3) 4.48 (3.12-7.17) <0.001 -0.331 (<0.001) -0.340 (<0.001)
hsCRP (mg/L) 0.480 (0.275-1.015) 0.690 (0.400-1.535) <0.001 0.380 (0.200-0.760) 0.750 (0.390-1.613) <0.001 0.163 (<0.001) 0.290 (<0.001)
GGT (IU/L) 35 (24-61) 55 (36-102) <0.001 20 (15-26) 25 (19-35) <0.001 0.240 (<0.001) 0.328 (<0.001)
  1. Data presented are mean ± standard deviation. Metabolic syndrome was defined as having three or more of the following conditions: obesity, raised blood pressure, hypertriglyceridemia, low HDL- cholesterolemia, and impaired fasting blood glucose. Data for triglycerides, fasting blood glucose, HOMA-IR, HMW adiponectin, hsCRP, and GGT were skewed and are presented as median (interquartile range) values, and were log-transformed for analysis. *P-value from Student's t-test for continuous variables or from χ2-test for categorical variables.