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Table 3 Hazard ratios of use of statin and fibrate for risk of cardiovascular disease in Chinese type 2 diabetic patients

From: Lipid control and use of lipid-regulating drugs for prevention of cardiovascular events in Chinese type 2 diabetic patients: a prospective cohort study

Exposures

HR

95%CI

P value

In the entire cohort§†

   

Use of statins during follow-up

0.66

0.50 to 0.88

.0038

Use of fibrates during follow-up

0.61

0.37 to 1.03

.0640

In the sub-cohort with LDL-C < 3.0 mmol/L¶, §

   

Use of statins during follow-up

1.10

0.56 to 2.16

.7798

Use of fibrates during follow-up

0.34

0.12 to 1.00

.0495

In the sub-cohort with LDL-C ≥ 3.0 mmol/L¶, §

   

Use of statins during follow-up

0.60

0.44 to 0.82

.0012

Use of fibrates during follow-up

0.65

0.35 to 1.19

.1590

In the sub-cohort with HDL-C < 1.0 mmol/L in male or 1.3 mmol/L in female ζ, §

   

Use of statins during follow-up

0.49

0.28 to 0.88

.0162

Use of fibrates during follow-up

0.37

0.13 to 1.09

.0703

In the sub-cohort with HDL-C ≥1.0 mmol/L in male or ≥ 1.3 mmol/L in female ζ, §

   

Use of statins during follow-up

0.73

0.53 to 1.02

.0662

Use of fibrates during follow-up

0.74

0.41 to 1.35

.3303

In the sub-cohort with metabolic syndrome at baseline ‡,§

   

Use of statins during follow-up

0.58

0.42 to 0.80

.0010

Use of fibrates during follow-up

0.60

0.35 to 1.05

.0713

In the sub-cohort without metabolic syndrome at baseline ‡,§

   

Use of statins during follow-up

0.77

0.42 to 1.44

.4201

Use of fibrates during follow-up

0.57

0.12 to 2.73

.4903

  1. †Adjusted for LDL-C (≥ 3.0 mmol/L vs. < 3.0 mmol/L), HDL-C, triglyceride, age, smoking status, duration of diabetes, HbA1c, Ln (ACR + 1), gliclazide and rosiglitazone during follow-up, years of enrolment (selected by the stepwise algorithm with P = .10 for entry and stay);
  2. Adjusted for the variables listed in ‡, except for LDL-C;
  3. ζ, Adjusted for the variables listed in ‡, except for HDL-C;
  4. §, Cox models stratified on deciles of probability of initiation of statin therapy during follow-up and on deciles of probability of initiation of fibrate therapy during follow-up.