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Table 2 Hemodynamic changes at the end of the study.

From: Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure

  Sham Operated (N = 10) Vehicle Control (N = 12) GLPL (N = 11) GLPH (N = 12) 3174L (N = 13) 3174H (N = 7)
Heart Rate (beats/min) 252 ± 13 268 ± 21 294 ± 20 295 ± 13 256 ± 16 312 ± 15
Mean BP (mmHg) 83 ± 5 80 ± 8 87 ± 7 84 ± 4 72 ± 2 83 ± 4
LVEDP (mmHg) 10.6 ± 0.9* 20.9 ± 1.4 12.7 ± 0.01* 12.3 ± 1.6* 14.4 ± 1.4* 13.9 ± 1.7*
+ dp/dt (mmHg/s) 5789 ± 430* 4426 ± 541 6157 ± 654* 6044 ± 284* 5234 ± 372 5948 ± 488*
-dp/dt (mmHg/s) 5826 ± 655* 3731 ± 564 5450 ± 652* 5582 ± 465* 4424 ± 386 5798 ± 592*
  1. Mean ± SEM. *P < 0.05 versus vehicle-treated group. BP, blood pressure; dp/dt, first derivative of left ventricular pressure over time.