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Table 2 Hemodynamic changes at the end of the study.

From: Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure

 

Sham Operated

(N = 10)

Vehicle Control

(N = 12)

GLPL

(N = 11)

GLPH

(N = 12)

3174L

(N = 13)

3174H

(N = 7)

Heart Rate (beats/min)

252 ± 13

268 ± 21

294 ± 20

295 ± 13

256 ± 16

312 ± 15

Mean BP (mmHg)

83 ± 5

80 ± 8

87 ± 7

84 ± 4

72 ± 2

83 ± 4

LVEDP (mmHg)

10.6 ± 0.9*

20.9 ± 1.4

12.7 ± 0.01*

12.3 ± 1.6*

14.4 ± 1.4*

13.9 ± 1.7*

+ dp/dt (mmHg/s)

5789 ± 430*

4426 ± 541

6157 ± 654*

6044 ± 284*

5234 ± 372

5948 ± 488*

-dp/dt (mmHg/s)

5826 ± 655*

3731 ± 564

5450 ± 652*

5582 ± 465*

4424 ± 386

5798 ± 592*

  1. Mean ± SEM. *P < 0.05 versus vehicle-treated group. BP, blood pressure; dp/dt, first derivative of left ventricular pressure over time.
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Cardiovascular Diabetology

ISSN: 1475-2840