Effect of chronic treatment with GLP-1 or AC3174 on cardiac function and survival. (A) Left ventricular ejection fraction (LVEF). At weeks 3 and 5 post-MI, 3174H LVEF was significantly less than GLPL LVEF (p < 0.05). At week 3 post-MI, 3174H LVEF was significantly less than 3174L LVEF (p < 0.05). (B) Doppler ratio for early (E) to late (A) transmitral flow velocity (E/A ratio). (C) Left ventricular end-diastolic dimension (LVEDD). (D) Left ventricular end-systolic dimension (LVESD). (E) Left atrial volume. (F) Kaplan-Meier survival curves. The number of chronic heart failure (CHF) related deaths (from 2 weeks post-MI) and the total number in each group were sham 0/10; control 4/16; GLPL 1/12; GLPH 0/12; 3174L 0/13 and 3174H 0/7. *p < 0.05 versus vehicle-treated control group.