Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus

Table 4 Determinants for presence of an estimated glomerular filtration rate <60 mL/min per 1.73 m² and coronary artery disease

Variable	Odds ratio	95% Confidence interval	P
Model A: Dependent variable moderate reduction in eGFR
Age	1.08	1.04-1.14	0.001
OPN	4.58	1.55-13.59	0.006
Model B: Dependent variable CAD
Sex	2.29	1.10-4.79	0.028
Statins	5.14	2.52-10.48	< 0.001
OPN	4.30	1.12-16.54	0.034
eGFR	0.20	0.05-0.82	0.026
Model C: Dependent variable moderate reduction in eGFR or CAD
Age	1.06	1.02 - 1.11	0.002
Statins	4.62	2.29 - 9.35	<0.001
OPN	4.49	1.18 - 17.05	0.027

Models A and C also included sex, cigarette smoking, systolic blood pressure (SBP), total cholesterol, triglyceride, lipoprotein (a), fasting glucose, use of angiotensin receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors (ACEI), use of statins, log-transformed thrombin-cleaved osteopontin (N-half OPN), and log-transformed high-sensitivity C-reactive protein (hsCRP). Model B also included cigarette smoking, SBP, total cholesterol, triglyceride, lipoprotein (a), fasting glucose, use of ARBs or ACEI, log-transformed N-half OPN, log-transformed hsCRP, and log-transformed estimated glomerular filtration rate (eGFR).

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